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首页> 外文期刊>Open Journal of Psychiatry >Differences in Baseline Characteristics of Patients Treated with Olanzapine or Other Antipsychotics in Japanese Patients with Acute Schizophrenia: A 1-Year Observational Study under Routine Clinical Practice in Japan
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Differences in Baseline Characteristics of Patients Treated with Olanzapine or Other Antipsychotics in Japanese Patients with Acute Schizophrenia: A 1-Year Observational Study under Routine Clinical Practice in Japan

机译：日本急性精神分裂症患者用奥氮平或其他抗精神病药治疗的患者基线特征的差异：日本常规临床实践下的1年观察性研究

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Objective: Baseline characteristics of acute schizophrenia patients were analyzed to identify differences in the baseline characteristics of patients treated with olanzapine monotherapy compared with those treated with other antipsychotic monotherapies. Methods: This prospective, naturalistic observational study was designed to evaluate discontinuation rates of olanzapine and non-olanzapine antipsychotic monotherapy in Japanese adult patients with acute schizophrenia. Results: A total of 1089 patients were assessed: 578 patients were treated with olanzapine, 487 with non-olanzapine atypical antipsychotics, and 24 with typical antipsychotics. The mean Clinical Global Impression-Severity (CGI-S) Schizophrenia, Brief Psychiatric Rating Scale (BPRS) total, and BPRS positive scores were higher in patients treated with olanzapine compared with most of the non-olanzapine treated patients. The majority of patients with a CGI-S Schizophrenia score of 7 (29/41 patients) as well as patients with a BPRS total score of 90 or higher (14/18 patients) were treated with olanzapine. On the other hand, physicians tended to prescribe antipsychotics other than olanzapine for patients with heavier body weight or diabetes mellitus. Conclusion: The present study demonstrated that olanzapine was more likely to be prescribed to patients with more severe schizophrenia symptoms. However, further studies are warranted to reach a definite conclusion.
机译：目的：分析急性精神分裂症患者的基线特征，以确定奥氮平单一疗法与其他抗精神病药物单一疗法相比基线特征的差异。方法：这项前瞻性，自然主义的观察性研究旨在评估日本成人急性精神分裂症患者中奥氮平和非奥氮平抗精神病药物单药的停用率。结果：总共评估了1089例患者：578例患者接受了奥氮平治疗，487例接受了非奥氮平非典型抗精神病药治疗，24例接受了典型抗精神病药治疗。与大多数非奥氮平治疗的患者相比，奥氮平治疗的患者的平均临床总体印象严重度（CGI-S）精神分裂症，简要精神病学评定量表（BPRS）和BPRS阳性评分更高。使用奥氮平治疗的大多数CGI-S精神分裂症得分为7的患者（29/41患者）以及BPRS总得分为90或更高的患者（14/18患者）。另一方面，对于体重较重或患有糖尿病的患者，除奥氮平外，医生倾向于开抗精神病药。结论：本研究表明奥氮平更可能用于精神分裂症症状较严重的患者。但是，有必要进一步研究得出明确的结论。

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