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首页> 外文期刊>Open Journal of Nursing >Effects of Prophylactic Laxatives for Opioid-Induced Constipation on Constipation Severity and Quality of Life among Patients with Cancer
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Effects of Prophylactic Laxatives for Opioid-Induced Constipation on Constipation Severity and Quality of Life among Patients with Cancer

机译：阿片类药物导致便秘的预防性泻药对癌症患者便秘程度和生活质量的影响

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Background: To reduce patients’ unnecessary suffering, Opioids Induced Constipation (OIC) should be identified and treated as early as possible with the most current treatment. Aims: to investigate the effectiveness of prophylactic laxatives in reducing the severity of OIC and its impact on cancer patients’ quality of life. Methods: A Randomized Clinical Trial design was used. 57 cancer patients from one oncology clinic at a governmental hospital participated in the study. Patients in the intervention groups were given an oral colonic stimulant laxative ( i.e. Bisacodyl, Dose = 3 tab/day) or an oral colonic osmotic laxative ( i.e. Lactulose, Dose = 15 ml three times per day), while patients in the control continue receiving their routine care as usual. Results: A significant decrease in the severity of constipation symptoms among the intervention group at four weeks post-intervention was noted (p < 0.001). In addition, there was a significant improvement in QOL among patients in the intervention group (p < 0.001) and no significant difference in the control group (p = 0.887). Conclusions: It can be concluded that the use prophylactic of first line laxatives concurrently with opioids decreased the severity of OIC and improved the QOL for cancer patients.
机译：背景：为减少患者不必要的痛苦，应确定阿片类药物引起的便秘（OIC）并尽早采用最新的治疗方法。目的：研究预防性泻药在降低OIC严重程度及其对癌症患者生活质量的影响方面的有效性。方法：采用随机临床试验设计。来自一家政府医院的一家肿瘤诊所的57位癌症患者参加了这项研究。干预组患者接受口服结肠刺激性泻药（即比沙可啶，剂量= 3片/天）或口服结肠渗透性泻药（即乳果糖，剂量= 15毫升，每天3次），而对照组患者继续接受照常进行日常护理。结果：干预后四周，干预组便秘症状的严重程度明显降低（p <0.001）。此外，干预组患者的生活质量显着改善（p <0.001），对照组无明显差异（p = 0.887）。结论：可以得出结论，一线泻药与阿片类药物并用的预防措施可降低癌症患者的OIC严重程度并改善QOL。

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