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首页> 外文期刊>Open Journal of Obstetrics and Gynecology >Eltrombopag Managed Severe Immune Thrombocytopenic Purpura in Pregnancy: A Case Report, Latifa Hospital, DHA, Dubai, UAE
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Eltrombopag Managed Severe Immune Thrombocytopenic Purpura in Pregnancy: A Case Report, Latifa Hospital, DHA, Dubai, UAE

机译：Eltrombopag管理的妊娠严重免疫性血小板减少性紫癜：一例病例报告，DHA Latifa医院，阿联酋迪拜

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摘要

Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder, defined by a platelet count of less than 100 × 10 ~( 9 ) /L, secondary to impaired production and immune destruction of platelets. Bleeding tendency is the main presentation of this condition. Clinical symptoms and investigations will confirm the diagnosis. Steroid is the first line of treatment. Although Rituximab and Thrombopoietin receptor agonists are useful second line agents in non-pregnant adults, the data about their role in pregnancy are still limited. We present the case of a 30 year old primigravida, who was a known case of chronic ITP since childhood; the course of her disease was fluctuating, for which oral steroids were used accordingly. She presented with gum bleeding and petechial rash with very low platelets count. She was sponsored by the Patient Support Program and was given Eltrombopag during the third trimester. She responded well to Eltrombopag with no noticeable side effects, neither to the mother nor to the baby so far. Eltrombopag has been assigned Category C by the Federal Drugs Agency (FDA) nevertheless there are no well controlled data in the literature about its role in pregnancy.
机译：免疫性血小板减少性紫癜（ITP）是一种获得性自身免疫性疾病，其定义为血小板计数低于100×10〜（9）/ L，继发于血小板生产受损和免疫破坏。出血趋势是这种情况的主要表现。临床症状和调查将确定诊断。类固醇是治疗的第一线。尽管利妥昔单抗和血小板生成素受体激动剂在非妊娠成年人中是有用的二线药物，但有关其在妊娠中作用的数据仍然有限。我们介绍了一个30岁的初产妇病例，该病例自儿童期就已成为慢性ITP的已知病例。她的病程在波动，为此口服了类固醇。她表现出牙龈出血和皮疹，血小板计数非常低。她是由患者支持计划赞助的，并在孕晚期获得了Eltrombopag的治疗。到目前为止，她对Eltrombopag的反应都很好，没有对母亲和婴儿都没有明显的副作用。 Eltrombopag已被联邦药品管理局（FDA）划为C类，但文献中没有关于其在妊娠中作用的良好控制数据。

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