Cyfra 21-1: An Overview

Jithin Jose; P.M. Sunil; R. Madhavan Nirmal; Soma Susan Varghese

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Cyfra 21-1: An Overview

机译：图21-1：概述

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Cytokeratins are group of intermediate filament proteins and based on the tissue expression, cytokeratins are classified into simple epithelial cytokeratin and stratified epithelial cytokeratins. CK expression pattern in the malignant cells are usually retained from the cell of origin, and therefore CK are being used in tumor typing. Cyfra 21-1 is a soluble fragment of cytokeratin 19 is an acid type cytokeratin, with a molecular weight of 40,000d. The assumption is that Cyfra 21-1 is released into the bloodstream during cell death, and therefore its level correlates very well with the tumour mass, or more specifically with the necrosis in the tumour, which is a function of the tumour mass. The aim of this article is to review on cyfra 21-1 and its role as a diagnostic and prognostic marker.

机译：细胞角蛋白是一组中间丝蛋白，根据组织表达，细胞角蛋白分为简单的上皮细胞角蛋白和分层的上皮细胞角蛋白。恶性细胞中的CK表达模式通常从原代细胞保留下来，因此CK被用于肿瘤分型。 Cyfra 21-1是细胞角蛋白的可溶片段，19是酸型细胞角蛋白，分子量为40,000d。假设是Cyfra 21-1在细胞死亡期间释放到血液中，因此其水平与肿瘤块，或更具体地与肿瘤坏死紧密相关，这是肿瘤块的函数。本文的目的是综述cyfra 21-1及其作为诊断和预后标志物的作用。

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《Oral & Maxillofacial Pathology Journal》 |2013年第2期|共页
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Jithin Jose; P.M. Sunil; R. Madhavan Nirmal; Soma Susan Varghese;
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中图分类口腔科学;
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Cyfra 21-1: An Overview

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