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首页> 外文期刊>Online Journal of Public Health Informatics >Seroprevalence and factors associated with seropositivity to Rift Valley fever virus in livestock
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Seroprevalence and factors associated with seropositivity to Rift Valley fever virus in livestock

机译：牲畜裂谷热病毒的血清阳性率和与血清阳性相关的因素

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Objective The objective of this study was to estimate the prevalence of antibodies to RVFV in domestic cattle, sheep, and goats in a study area in the central interior of South Africa, and to identify factors associated with seropositivity. Introduction Rift Valley fever (RVF) is a mosquito-borne viral zoonosis. This study aimed to estimate the prevalence of antibodies to RVF virus (RVFV) in cattle, sheep, and goats in South Africa, near the 2010-2011 outbreak epicenter and identify factors associated with seropositivity. Methods A cross-sectional study was conducted during 2015-2016 within a ~40,000 km 2 region between Bloemfontein and Kimberley. Farms were selected using random geographic points with probability proportional to the density of livestock-owning households. Livestock were randomly sampled from the farm closest to each selected point. A questionnaire was used to collect information concerning animal, management, and environmental factors. Sera samples were screened for RVFV antibodies using IgG inhibition ELISA. Data were analyzed using multilevel logistic regression models. Results On 234 farms, 3,049 animals (977 cattle, 1,549 sheep and 523 goats) were sampled. Estimated RVF seroprevalence, adjusted for clustering and sampling weights, was 42.9% (95% CI: 35.7-50.4%) in cattle, 28.0% (95% CI: 21.3-35.4%) in sheep and 9.3% (95% CI: 5.8-13.9%) in goats. Compared to animals 2y of age, seroprevalence was higher in animals 2-4y (OR=2.8, P 0.001) and 4y old (OR=17.0, P 0.001). Seroprevalence was also higher on private vs. communal land (OR=4.3, P =0.001) and was positively associated with the presence of perennial rivers (OR=1.6, P =0.03) and seasonal pans (OR=1.8, P =0.005) on the farm. The odds of seropositivity was higher in domestic ruminants recently vaccinated between 2014-2015 (OR=2.1, P =0.007) compared to those never vaccinated. Conclusions The presence of IgG antibody against RVFV among domestic ruminants, born after the most recent outbreak (4y category), and association with known RVF risk factors, indicates the possibility that viral circulation has occurred during the inter-epidemic period.
机译：目的这项研究的目的是评估南非中部一个研究区域内家畜，绵羊和山羊中RVFV抗体的流行情况，并确定与血清阳性有关的因素。简介裂谷热（RVF）是一种由蚊子传播的病毒人畜共患病。这项研究旨在评估2010-2011年爆发震中附近南非，牛，绵羊和山羊中RVF病毒（RVFV）抗体的流行程度，并确定与血清阳性有关的因素。方法在2015年至2016年期间，在布隆方丹和金伯利之间约40,000 km 2的区域内进行了横断面研究。使用随机地理位置选择农场，概率与拥有牲畜的家庭的密度成正比。从距离每个选定点最近的农场中随机取样牲畜。使用问卷调查收集有关动物，管理和环境因素的信息。使用IgG抑制ELISA筛选血清样品中的RVFV抗体。使用多级逻辑回归模型分析数据。结果在234个农场中，共采样了3049只动物（977头牛，1549头绵羊和523只山羊）。经过聚类和抽样权重调整后的估计RVF血清阳性率在牛中为42.9％（95％CI：35.7-50.4％），在绵羊中为28.0％（95％CI：21.3-35.4％）在绵羊中为9.3％（95％CI：5.8） -13.9％）。与2岁以下的动物相比，2-4岁的动物（OR = 2.8，P <0.001）和4岁以上的动物（OR = 17.0，P <0.001）的血清阳性率更高。私人土地和公共土地上的血清阳性率也较高（OR = 4.3，P = 0.001），并且与多年生河流（OR = 1.6，P = 0.03）和季节性泛滥（OR = 1.8，P = 0.005）呈正相关。在农场。与从未接种过的反刍动物相比，2014-2015年间刚接种过的反刍动物血清阳性的几率更高（OR = 2.1，P = 0.007）。结论最近一次暴发（<4y类）后出生的家养反刍动物中存在针对RVFV的IgG抗体，并且与已知的RVF危险因素有关，这表明在流行期间可能发生了病毒循环。

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