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首页> 外文期刊>Ophthalmology and Eye Diseases >Ocular Surface Cytotoxicity and Safety Evaluation of Tafluprost, a Recently Developed Anti-Glaucoma Prostaglandin Analog
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Ocular Surface Cytotoxicity and Safety Evaluation of Tafluprost, a Recently Developed Anti-Glaucoma Prostaglandin Analog

机译：Tafluprost（一种新近开发的抗青光眼前列腺素类似物）的眼表细胞毒性和安全性评估

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摘要

In vitro cytotoxicity of tafluprost, which is the most recently developed anti-glaucoma prostaglandin (PG) analog, in ocular surface cells is addressed in comparison with other PG analogs. Irrespective of cell lines and models, the cytotoxicity of anti-glaucoma PG eyedrops was primarily related to the concentration of benzalkonium chloride (BAK) contained in the eyedrops as a preservative. Accordingly, preservative-free tafluprost was apparently less cytotoxic than BAK-preserved PG analogs. Furthermore, our study for cytotoxicity assays on ocular cells, conducted by comprehensive investigations covering a variety of concentrations and treatment times, which is termed the cell viability score (CVS) system, demonstrated that 0.001% BAK-preserved tafluprost was not cytotoxic, and suggested that tafluprost may even reduce the cytotoxic effect of BAK.It has been reported that adverse reactions associated with tafluprost in healthy human volunteers and patients with glaucoma include conjunctival hyperemia, eyelid pigmentation, eyelash bristles, and deepening of upper eyelid sulcus. Nonetheless, most clinical studies have demonstrated that not only preservative-free tafluprost but also BAK-preserved tafluprost is well tolerated and safe in patients with glaucoma and ocular hypertension.
机译：与其他PG类似物相比，可解决塔氟前列素（tafluprost）在眼表面细胞中的体外细胞毒性，它是最近开发的抗青光眼前列腺素（PG）类似物。无论细胞系和模型如何，抗青光眼PG滴眼液的细胞毒性主要与滴眼液中作为防腐剂的苯扎氯铵（BAK）的浓度有关。因此，不含防腐剂的他氟前列素明显比保存BAK的PG类似物具有更低的细胞毒性。此外，我们针对眼部细胞进行细胞毒性测定的研究，是通过对多种浓度和治疗时间进行的综合研究进行的，该研究被称为细胞生存力评分（CVS）系统，该研究表明0.001％的BAK保留的tafluprost没有细胞毒性，因此建议据报道，在健康的人类志愿者和青光眼患者中，与tafluprost相关的不良反应包括结膜充血，眼睑色素沉着，睫毛刚毛和上眼睑沟的加深。尽管如此，大多数临床研究表明，对于青光眼和高眼压患者，不仅不含防腐剂的他氟前列素而且BAK防腐的他氟前列素都具有良好的耐受性和安全性。

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