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首页> 外文期刊>RGUHS Journal of Pharmaceutical Sciences >Simultaneous Estimation and Validation of Niacin and Atorvastatin Calcium by UV-Spectroscopy in Pure and Tablet Dosage Form Using Methanol: Water Mixture as Solvent
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Simultaneous Estimation and Validation of Niacin and Atorvastatin Calcium by UV-Spectroscopy in Pure and Tablet Dosage Form Using Methanol: Water Mixture as Solvent

机译：使用甲醇：水混合物作为溶剂，通过纯净和片剂剂量形式的紫外光谱同时估算和验证烟酸和阿托伐他汀钙

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Purpose of This paper: Two simple, precise, rapid, sensitive and accurate simultaneous estimation by UV spectrophotometric methods were developed and validated for niacin (NCN) and atorvastatin calcium (ATR) in pure and tablet dosage form using methanol: water (40:60 v/v)mixture as solvent. Design and methodology: Two methods were developed, Method 1: was based on the simultaneous equation (Veroirdt's) method where as Method 2:was based on Q-analysis method. Findings: The absorption maxima were found to be 262 nm and 246 nm for niacin and atorvastatin calcium respectively. Both the drugs showed isosbestic point at 250 nm. Beer’s range was in the concentration range of 10-50 μg/ml for niacin and 4-20 μg/ml for atorvastatin calcium with correlation coefficient within the range of 0.9974 – 0.9998 for both the drugs. Recovery studies were performed to assess the accuracy of the methods, the results were found to be between 99.39 ± 0.7614 and 100.63 ± 0.3876 for niacin; 97. 71 ± 0.3131 and 99.06 ± 0.5625 for atorvastatin calcium. Research implications/limitations: The above two methods has been validated according to ICH guidelines. Practical implications: Hence the above methods can be used for routine analysis of NCN and ATR in pharmaceutical industries and research institutions.
机译：本文的目的：开发了两种简单，精确，快速，灵敏和准确的同时紫外分光光度法估计方法，并使用甲醇：水（40:60）对纯品和片剂剂型中的烟酸（NCN）和阿托伐他汀钙（ATR）进行了验证。 v / v）混合物作为溶剂。设计和方法：开发了两种方法，方法1：基于联立方程（Veroirdt's）方法，而方法2：基于Q分析方法。结果：发现烟酸和阿托伐他汀钙的最大吸收分别为262 nm和246 nm。两种药物均在250 nm处显示等渗点。烟酸的啤酒浓度范围是10-50μg/ ml，阿托伐他汀钙的浓度范围是4-20μg/ ml，两种药物的相关系数都在0.9974-0.9998的范围内。进行了回收率研究以评估该方法的准确性，烟酸的结果介于99.39±0.7614和100.63±0.3876之间;阿托伐他汀钙为97. 71±0.3131和99.06±0.5625。研究意义/局限性：以上两种方法均已根据ICH指南进行了验证。实际意义：因此，上述方法可用于制药行业和研究机构中NCN和ATR的常规分析。

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