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首页> 外文期刊>Open Journal of Urology >Comparison between Different Modalities of Treatment of Ewing Sarcoma
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Comparison between Different Modalities of Treatment of Ewing Sarcoma

机译：尤文氏肉瘤不同治疗方式的比较

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Background: Ewing sarcoma is the most common primary malignant tumour in patients younger than 10 years of age. The incidence is less than 1 per 1 million per year. Usually it is located in the diaphysis of long bones. Prognosis of these tumours has improved dramatically since the introduction of multi-agent chemotherapy, from an erstwhile 10% survival rate to the current 70% for patients with non-metastatic Ewing sarcoma. Method: A retrospective review of patients with histologically confirmed Ewing sarcoma who were treated in the Department of Orthopaedics, B.S. Medical College during the time period from April 2000 to March 2012 was performed. Patients were divided into two groups: Group A included those treated by External Beam Radiotherapy (EBRT) + chemotherapy while Group B included the patients treated with surgery + chemotherapy. Results were analysed depending on the survival rates. Kaplan-Meier survival curves were compared using log-rank test and a multivariate Cox proportional hazards model was calculated. Result: The survival curves of both the groups were not found to be significantly different. Conclusion: Treatment of Ewing tumour has multiple options. No one treatment modality is superior. Survival rates of patients treated by radiation + chemotherapy are not significantly different from those treated with surgery + chemotherapy.
机译：背景：尤文肉瘤是10岁以下患者中最常见的原发性恶性肿瘤。每年的发病率少于百万分之一。通常它位于长骨的骨干中。自从采用多剂化疗以来，这些肿瘤的预后有了显着改善，从以前的10％生存率到目前的非转移性尤因肉瘤患者的70％生存率。方法：回顾性回顾了在B.S.骨科的组织学证实的尤因肉瘤患者在2000年4月至2012年3月这段时间进行了医学院的研究。患者分为两组：A组包括接受外照射治疗（EBRT）+化疗的患者，B组包括接受手术+化疗的患者。根据存活率分析结果。使用对数秩检验比较Kaplan-Meier生存曲线，并计算多元Cox比例风险模型。结果：两组的生存曲线均无显着差异。结论：尤因肿瘤的治疗有多种选择。没有一种治疗方法是优越的。放射线+化学疗法治疗的患者的存活率与手术+化学疗法治疗的患者的生存率没有显着差异。

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