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首页> 外文期刊>Ophthalmology Management >MKO Melt: Here is what we’ve learned
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MKO Melt: Here is what we’ve learned

机译：MKO Melt：这是我们学到的

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EVOLUTIONCataract surgery continues to evolve. After safety was mastered, surgeons, and industry, made improved refractive outcomes their goal. Now, the focus is on improving a patient’s overall experience. For many patients, a major source of anxiety is administration of the intravenous line. Some patients have difficulty with administration of the IV due to poor accessibility of their veins. Many patients associate anticipation of the IV with pain, or the perception of it. These patients consider the pain they associate with the IV needle stick likely worse than the pain experienced during cataract surgery.The MKO Melt has helped these patients. The Melt is an IV-free conscious sedation compounded formulation. It consists of 3 mg of midazolam (Versed, Roche), 25 mg of ketamine HCl, and 2 mg of ondansetron (Zofran, GSK). It is delivered as a single-use prescription for each patient. Initially lemon flavored, the Melt eventually becomes slightly bitter.During the development of this product, midazolam was chosen as one of the primary components since it is frequently used during cataract surgery. It provides a good anxiolytic effect with a rapid on and off effect. Ketamine delivers analgesia with a mild amount of euphoria. It also provides for a “ketamine stare,” enabling patients to look at the microscope light rather than away from it.The dosage of ketamine in the melt is much less than what is typically administered IV, resulting in fewer untoward side effects.
机译：演化白内障手术在不断发展。掌握安全性之后，外科医生和行业将改善屈光结果作为目标。现在，重点是改善患者的整体体验。对于许多患者来说，焦虑的主要来源是静脉注射。一些患者由于静脉的可及性差而难以进行静脉注射。许多患者将静脉注射的预期与疼痛或对疼痛的感知联系起来。这些患者认为与IV针刺相关的疼痛可能比白内障手术时所遭受的疼痛更严重.MKO Melt帮助了这些患者。熔体是无静脉镇静的复合配方。它由3 mg咪达唑仑（Versed，Roche），25 mg氯胺酮HCl和2 mg恩丹西酮（Zofran，GSK）组成。它作为每位患者的一次性处方提供。最初具有柠檬味，但熔体最终变得略带苦味。在该产品的开发过程中，咪达唑仑被选为主要成分之一，因为它在白内障手术中经常使用。它提供了良好的抗焦虑作用，并具有快速的开关作用。氯胺酮提供镇痛作用，并带有少量的兴奋感。它还提供了“氯胺酮凝视”，使患者能够看着显微镜的光线而不是远离它。熔体中氯胺酮的剂量比静脉注射通常要少得多，从而减少了不良的副作用。

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