• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Orthopaedic Journal of Sports Medicine >Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR
【24h】

Persistent Biomechanical Alterations After ACL Reconstruction Are Associated With Early Cartilage Matrix Changes Detected by Quantitative MR

机译：ACL重建后持久的生物力学变化与定量MR检测到的早期软骨基质变化有关

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background: The effectiveness of anterior cruciate ligament (ACL) reconstruction in preventing early osteoarthritis is debated. Restoring the original biomechanics may potentially prevent degeneration, but apparent pathomechanisms have yet to be described. Newer quantitative magnetic resonance (qMR) imaging techniques, specifically T_(1ρ)and T_(2), offer novel, noninvasive methods of visualizing and quantifying early cartilage degeneration. Purpose: To determine the tibiofemoral biomechanical alterations before and after ACL reconstruction using magnetic resonance imaging (MRI) and to evaluate the association between biomechanics and cartilage degeneration using T_(1ρ)and T_(2). Study Design: Cohort study; Level of evidence, 2. Methods: Knee MRIs of 51 individuals (mean age, 29.5 ± 8.4 years) with unilateral ACL injuries were obtained prior to surgery; 19 control subjects (mean age, 30.7 ± 5.3 years) were also scanned. Follow-up MRIs were obtained at 6 months and 1 year. Tibial position (TP), internal tibial rotation (ITR), and T_(1ρ)and T_(2)were calculated using an in-house Matlab program. Student t tests, repeated measures, and regression models were used to compare differences between injured and uninjured sides, observe longitudinal changes, and evaluate correlations between TP, ITR, and T_(1ρ)and T_(2). Results: TP was significantly more anterior on the injured side at all time points ( P < .001). ITR was significantly increased on the injured side prior to surgery ( P = .033). At 1 year, a more anterior TP was associated with elevated T_(1ρ)( P = .002) and T_(2)( P = .026) in the posterolateral tibia and with decreased T_(2)in the central lateral femur ( P = .048); ITR was associated with increased T_(1ρ)in the posteromedial femur ( P = .009). ITR at 6 months was associated with increased T_(1ρ)at 1 year in the posteromedial tibia ( P = .029). Conclusion: Persistent biomechanical alterations after ACL reconstruction are related to significant changes in cartilage T_(1ρ)and T_(2)at 1 year postreconstruction. Longitudinal correlations between ITR and T_(1ρ)suggest that these alterations may be indicative of future cartilage injury, leading to degeneration and osteoarthritis. Clinical Relevance: Newer surgical techniques should be developed to eliminate the persistent anterior tibial translation commonly seen after ACL reconstruction. qMR will be a useful tool to evaluate the ability of these newer techniques to prevent cartilage changes.
机译：背景：前交叉韧带（ACL）重建在预防早期骨关节炎中的有效性尚有争议。恢复原始生物力学可以潜在地防止退化，但是尚未描述明显的病理机制。较新的定量磁共振（qMR）成像技术，特别是T_（1ρ）和T_（2），提供了可视化和量化早期软骨变性的新颖，无创方法。目的：利用磁共振成像（MRI）确定ACL重建前后的胫股生物力学变化，并利用T_（1ρ）和T_（2）评估生物力学与软骨变性之间的关联。研究设计：队列研究;证据级别：2。方法：术前先行51例单侧ACL损伤的膝部MRI（平均年龄29.5±8.4岁）。还对19名对照受试者（平均年龄30.7±5.3岁）进行了扫描。在6个月和1年时进行了MRI随访。使用内部Matlab程序计算胫骨位置（TP），胫骨内部旋转（ITR）以及T_（1ρ）和T_（2）。使用学生t检验，重复测量和回归模型比较受伤侧和未受伤侧之间的差异，观察纵向变化，并评估TP，ITR以及T_（1ρ）和T_（2）之间的相关性。结果：TP在所有时间点均在受伤侧更向前（P <.001）。术前受伤侧ITR显着增加（P = .033）。在第1年时，胫后外侧的T_（1ρ）（P = .002）和T_（2）（P = .026）升高与TP升高有关，而股骨中央外侧T_（2）降低则与前TP相关（ P = .048）; ITR与后内侧股骨T_（1ρ）增加有关（P = .009）。后胫骨第1个月的6个月ITR与T_（1ρ）增加有关（P = .029）。结论：ACL重建后持久的生物力学改变与重建后1年软骨T_（1ρ）和T_（2）的显着变化有关。 ITR和T_（1ρ）之间的纵向相关性表明这些改变可能预示着将来的软骨损伤，从而导致变性和骨关节炎。临床意义：应该开发更新的外科手术技术，以消除ACL重建后常见的持续性胫骨前移。 qMR将是评估这些新技术防止软骨变化的能力的有用工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号