Apoptosis promotes early tumorigenesis

D Tang; M T Lotze; R Kang; H J Zeh

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Apoptosis promotes early tumorigenesis

机译：凋亡促进早期肿瘤发生

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One hallmark of cancer is intrinsic or acquired resistance to apoptosis. Surprisingly, recent studies demonstrate that CD95/Fas/Apo1 and p53 upregulated mediator of apoptosis/PUMA (potent inducers of the death receptor and the mitochondrial apoptotic pathways, respectively) promote tumorigenesis. These findings provide important insights into the multifaceted roles of apoptosis in tumorigenesis.

机译：癌症的一个标志是对细胞凋亡的内在或获得性抗性。令人惊讶的是，最近的研究表明CD95 / Fas / Apo1和p53上调了凋亡/ PUMA的介体（分别是死亡受体和线粒体凋亡途径的有效诱导剂）促进了肿瘤的发生。这些发现为凋亡在肿瘤发生中的多方面作用提供了重要的见识。

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《Oncogene》 |2011年第16期|共4页
作者
D Tang; M T Lotze; R Kang; H J Zeh;
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中图分类肿瘤学;
关键词
tumorigenesisCD95PUMAapoptosis;

机译：肿瘤发生CD95PUMA凋亡;

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1. SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway [J] . Jiang Tao, Chen Zhao-Hui, Chen Zhe, Brazilian Journal of Medical and Biological Research . 2020,第2期

机译：Sulf2促进肿瘤发生，并通过ERK / AKT信号通路抑制宫颈癌细胞的凋亡
2. GGN Promotes Tumorigenesis by Regulating Proliferation and Apoptosis in Colorectal Cancer [J] . Zheng Liu, Ming Yang, Song Wang, Pathology oncology research: POR . 2019,第4期

机译：通过调节结肠直肠癌的增殖和凋亡，GGN促进肿瘤内酯
3. GGN Promotes Tumorigenesis by Regulating Proliferation and Apoptosis in Colorectal Cancer [J] . Liu Zheng, Yang Ming, Wang Song, Pathology oncology research: POR . 2019,第4期

机译：GGN通过调节结肠直肠癌的增殖和细胞凋亡来促进肿瘤发生
4. Tumor promoting mechanism of biomaterials: No involvement of mutation in cx43 gene in the tumorigenesis induced by polyurethanes in vitro [C] . Toshie Tsuchiya, Md. Abu Sayed, Akitada Nakamura Joint International Meeting of the Japanese Association for Animal Cell Technolog and and European Society for Animal Cell Technology . 1999

机译：生物材料的肿瘤促进机制：在体外聚氨酯诱导的CX43基因中突变中的突变缺失
5. Apoptosis-inducing Factor Mediates Metabolism and Oxidative Stress Signaling Through Functionally Uncoupled Mechanisms to the Benefit of Tumorigenesis [D] . Scott, Andrew Joseph 2019

机译：凋亡诱导因子通过功能不耦合的机制介导代谢和氧化应激信号传导，以促进肿瘤发生。
6. SULF2 promotes tumorigenesis and inhibits apoptosis of cervical cancer cells through the ERK/AKT signaling pathway [O] . Tao Jiang, Zhao-Hui Chen, Zhe Chen, 2020

机译：SULF2通过ERK / AKT信号通路促进宫颈癌的发生并抑制宫颈癌细胞的凋亡
7. CDC20 Knockdown and Acidic Microenvironment Collaboratively Promote Tumorigenesis through Inhibiting Autophagy and Apoptosis [O] . Qingying Gu, Fang Li, Shengfang Ge, 2020

机译：CDC20敲低和酸性微环境通过抑制自噬和细胞凋亡来协作促进肿瘤发生

Apoptosis promotes early tumorigenesis

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