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首页> 外文期刊>Oncogene >SV40 in human brain cancers and non-Hodgkin's lymphoma
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SV40 in human brain cancers and non-Hodgkin's lymphoma

机译：SV40在人脑癌和非霍奇金淋巴瘤中的应用

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Simian virus 40 (SV40) is a potent DNA tumor virus that is known to induce primary brain cancers and lymphomas in laboratory animals. SV40 oncogenesis is mediated by the viral large tumor antigen (T-ag), which inactivates the tumor-suppressor proteins p53 and pRb family members. During the last decade, independent studies using different molecular biology techniques have shown the presence of SV40 DNA, T-ag, or other viral markers in primary human brain cancers, and a systematic assessment of the data indicates that the virus is significantly associated with this group of human tumors. In addition, recent large independent studies showed that SV40 T-ag DNA is significantly associated with human non-Hodgkin's lymphoma (NHL). Although the prevalence of SV40 infections in humans is not known, numerous observations suggest that SV40 is a pathogen in the human population today. This review examines the molecular biology, pathology, and clinical data implicating SV40 in the pathogenesis of primary human brain cancers and NHL and discusses future research directions needed to define a possible etiologic role for SV40 in these malignancies.
机译：猿猴病毒40（SV40）是一种有效的DNA肿瘤病毒，已知会在实验动物中诱发原发性脑癌和淋巴瘤。 SV40的肿瘤发生是由病毒大肿瘤抗原（T-ag）介导的，它可以使肿瘤抑制蛋白p53和pRb家族成员失活。在过去的十年中，使用不同的分子生物学技术进行的独立研究表明，SV40 DNA，T-ag或其他病毒标记物存在于原发性人脑癌中，对这些数据的系统评估表明，该病毒与这种病毒显着相关人类肿瘤。此外，最近的大型独立研究表明，SV40 T-ag DNA与人类非霍奇金淋巴瘤（NHL）显着相关。尽管尚不知道SV40感染在人类中的普遍程度，但大量观察表明，SV40是当今人类的病原体。这篇综述检查了涉及SV40与原发性人脑癌和NHL发病机理有关的分子生物学，病理学和临床数据，并讨论了确定SV40在这些恶性肿瘤中可能的病因作用所需的未来研究方向。

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