Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

HJ Kwun; JA Wendzicki; Y Shuda; PS Moore; Y Chang

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Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

机译：默克尔细胞多瘤病毒小T抗原通过E3泛素连接酶靶向诱导基因组不稳定

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The formation of a bipolar mitotic spindle is an essential process for the equal segregation of duplicated DNA into two daughter cells during mitosis. As a result of deregulated cellular signaling pathways, cancer cells often suffer a loss of genome integrity that might etiologically contribute to carcinogenesis. Merkel cell polyomavirus (MCV) small T (sT) oncoprotein induces centrosome overduplication, aneuploidy, chromosome breakage and the formation of micronuclei by targeting cellular ligases through a sT domain that also inhibits MCV large T oncoprotein turnover. These results provide important insight as to how centrosome number and chromosomal stability can be affected by the E3 ligase targeting capacity of viral oncoproteins such as MCV sT, which may contribute to Merkel cell carcinogenesis.

机译：双极有丝分裂纺锤体的形成是在有丝分裂过程中将复制的DNA均等地分离成两个子细胞的必不可少的过程。由于细胞信号通路的失控，癌细胞经常遭受基因组完整性的丧失，这可能在病因上有助于癌变。默克尔细胞多瘤病毒（MCV）小T（sT）癌蛋白通过通过sT域靶向细胞连接酶来诱导中心体过度复制，非整倍性，染色体断裂和微核的形成，这也抑制了MCV大T癌蛋白的更新。这些结果提供了关于病毒癌蛋白（例如MCV sT）的E3连接酶靶向能力如何影响中心体数目和染色体稳定性的重要见解，这可能有助于默克尔细胞癌变。

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《Oncogene》 |2017年第49期|共9页
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HJ Kwun; JA Wendzicki; Y Shuda; PS Moore; Y Chang;
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中图分类肿瘤学;
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1. Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCF~(Fbw7) [J] . Hyun Jin Kwun, Masahiro Shuda, Huichen Feng, Cell Host & Microbe . 2013,第2期

机译：默克尔细胞多瘤病毒小T抗原通过靶向细胞泛素连接酶SCF〜（Fbw7）控制病毒复制和癌蛋白表达。
2. Merkel cell polyomavirus Tumor antigens expressed in Merkel cell carcinoma function independently of the ubiquitin ligases Fbw7 and ?2-TrCP [J] . Kristine N. Dye, Markus Welcker, Bruce E. Clurman, PLoS Pathogens . 2019,第1期

机译：默克尔细胞多瘤病毒默克尔细胞癌中表达的肿瘤抗原的功能与泛素连接酶Fbw7和β2-TrCP无关
3. Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+T cell mediated immune response [J] . Progress in Artificial Intelligence . 2020,第1期

机译：靶向泛素蛋白质连接酶E3组分N-鉴定癌细胞诱导CD8 + T细胞介导的免疫反应
4. THE E3 UBIQUITIN LIGASE CBL-B REVERSES MULTIDRUG RESISTANCE OF MCF-7/ADR CELLS THROUGH SUPPRESSION OF PI3K/AKT SIGNALING PATHWAY AND DOWN-REGULATION OF P-GLYCOPROTEIN [C] . Ye Zhang, Xiujuan Qu, Xuejun Hu, 2011 Asia-Pacific Conference of tumor biology and medicine . 2011

机译：E3泛素连接酶CBL-B通过抑制PI3K / AKT信号通路和P-糖蛋白下调逆转MCF-7 / ADR细胞的多药耐药性
5. A Novel Target of HDAC6’S E3 Ubiquitin Ligase Activity, CHK1, Is Responsible for the Sensitization of Non-Small Cell Lung Cancer Cells to Ionizing Radiation [D] . ?Moses, Niko Ambrose 2020

机译：HDAC6 的E3 泛素连接酶活， CHK1，一种新的目标负责用于非小细胞肺癌细胞的致敏在电离辐射
6. Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting [O] . H J Kwun, J A Wendzicki, Y Shuda, -1

机译：默克尔细胞多瘤病毒小T抗原通过E3泛素连接酶靶向诱导基因组不稳定
7. Merkel Cell Polyomavirus Small T Antigen Controls Viral Replication and Oncoprotein Expression by Targeting the Cellular Ubiquitin Ligase SCFFbw7 [O] . Kwun Hyun Jin, Shuda Masahiro, Feng Huichen, 2013

机译：默克尔细胞多瘤病毒小T抗原通过靶向细胞泛素连接酶SCFFbw7控制病毒复制和癌蛋白表达。

Merkel cell polyomavirus small T antigen induces genome instability by E3 ubiquitin ligase targeting

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