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Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia

机译：结肠癌分泌蛋白2（CCSP-2），一种结肠肿瘤的新型血清学标志物

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Cancers of the colon and rectum are the second leading cause of cancer death among adult Americans. When detected at early stages, colon cancer is highly curable. Colonoscopy, an effective but invasive screening test, has been limited in its public acceptance. The goal of this study was to identify novel serum markers of colon cancers and precancerous colon adenomas as potential candidates for noninvasive detection of early colon neoplasms. Employing expression microarrays, we identified colon cancer secreted protein-2 (CCSP-2) as a novel transcript whose expression is generally absent in normal colon and other normal body tissues, but that is induced an average of 78-fold in Stage II, III, and IV colon cancers, as well as in colon adenomas and colon cancer cell lines. These findings were validated by real-time PCR analysis in an independent panel of colon cancer cases. Moreover, CCSP-2 was shown to encode a secreted protein that circulates stably and is detectable in the blood of mice bearing human cancer xenografts transfected with epitope-tagged CCSP-2. As a novel secreted protein that is markedly induced in colon adenomas and cancers, CCSP-2 is a novel candidate for development as a diagnostic serum marker of early stage colon cancer.
机译：结肠癌和直肠癌是成年美国人中癌症死亡的第二大主要原因。在早期发现时，结肠癌可以高度治愈。结肠镜检查是一种有效的但具有侵入性的筛查测试，但其在公众中的接受程度受到限制。这项研究的目的是确定结肠癌和癌前结肠腺瘤的新型血清标志物，作为无创检测早期结肠肿瘤的潜在候选者。利用表达微阵列，我们将结肠癌分泌蛋白2（CCSP-2）鉴定为一种新的转录本，其在正常结肠和其他正常人体组织中通常不表达，但在II，III期平均被诱导78倍和IV结肠癌，以及结肠腺瘤和结肠癌细胞系。这些发现已通过独立的一组结肠癌病例中的实时PCR分析得到验证。此外，显示出CCSP-2编码一种分泌的蛋白，该蛋白稳定循环并在携带人癌异种移植物的小鼠血液中可检测到，该小鼠被表位标记的CCSP-2转染。作为在结肠腺瘤和癌症中显着诱导的新型分泌蛋白，CCSP-2是开发为早期结肠癌的诊断血清标志物的新型候选药物。

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