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首页> 外文期刊>Schizophrenia Research >Neuroscience-informed auditory training in schizophrenia: A final report of the effects on cognition and serum brain-derived neurotrophic factor
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Neuroscience-informed auditory training in schizophrenia: A final report of the effects on cognition and serum brain-derived neurotrophic factor

机译：神经科学指导的精神分裂症听觉训练：对认知和血清脑源性神经营养因子影响的最终报告

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Objective We previously reported the interim effects in a per protocol analysis of a randomized controlled trial of an innovative neuroscience-informed computerized cognitive training approach in schizophrenia. Here we report the effects of training on behavioral outcome measures in our final sample using an intent-to-treat analysis. We also report the effects on serum brain-derived neurotrophic factor (BDNF). Method Eighty-seven clinically stable participants with schizophrenia were randomly assigned to either targeted auditory training (AT, N=46) or a computer games control condition (CG, N=41). Participants were assessed on neurocognition, symptoms and functional outcome at baseline and after 50 hours of intervention delivered over 10 weeks. Serum BDNF was assessed at baseline, at 2 weeks, and at 10 weeks. Results After the intervention, AT participants showed significant gains in global cognition, speed of processing, verbal learning, and verbal memory, relative to CG participants, with no changes in symptoms or functioning. At baseline, schizophrenia participants had significantly lower-than-normal serum BDNF. AT participants showed a significant increase in serum BDNF compared to CG participants, and “normalized” levels by post training. Conclusions Participants with chronic schizophrenia made significant cognitive gains after 50 hours of intensive computerized training delivered as a stand-alone treatment, but no improvement in symptoms or functioning. Serum BDNF levels were significantly increased, and may serve as a peripheral biomarker for the effects of training. Future research must focus on: 1) Methods of integrating cognitive training with psychosocial treatments; 2) A deeper understanding of underlying neurophysiology in order to enhance critical mechanisms of action.
机译：目的我们先前在一项针对精神分裂症的创新性神经科学信息化计算机认知训练方法的随机对照试验的按方案分析中报告了中期效果。在这里，我们使用意向性分析报告了培训对最终样本中行为结果测度的影响。我们还报告了对血清脑源性神经营养因子（BDNF）的影响。方法将八十七名临床稳定的精神分裂症患者随机分配到目标听觉训练（AT，N = 46）或计算机游戏控制条件（CG，N = 41）。在基线时以及在10周内进行50个小时的干预后，评估参与者的神经认知，症状和功能结局。在基线，2周和10周时评估血清BDNF。结果干预后，与CG参与者相比，AT参与者在整体认知，处理速度，言语学习和言语记忆方面均表现出显着提高，而症状或功能没有变化。基线时，精神分裂症患者的血清BDNF明显低于正常水平。与CG参与者相比，AT参与者显示血清BDNF显着增加，并且训练后达到“正常”水平。结论慢性精神分裂症患者经过50个小时的强化计算机培训作为独立治疗后，可显着提高认知能力，但症状或功能无改善。血清BDNF水平显着增加，并且可以作为训练效果的外周生物标志物。未来的研究必须集中在：1）将认知训练与社会心理治疗相结合的方法; 2）更深入地了解潜在的神经生理学，以增强关键的作用机制。

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