• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Schizophrenia Research >Decoding emotion of the other differs among schizophrenia patients and schizoaffective patients: A pilot study
【24h】

Decoding emotion of the other differs among schizophrenia patients and schizoaffective patients: A pilot study

机译：一项精神分裂症患者和精神分裂症患者的另一种情感解读有所不同

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The deficit in ability to attribute mental states such as thoughts, beliefs, and intentions of another person is a key component in the functional impairment of social cognition in schizophrenia. In the current study, we compared the ability of persons with first episode schizophrenia (FE-SZ) and individuals with schizophrenia displaying symptomatic remission (SZ-CR) to decode the mental state of others with healthy individuals and schizoaffective patients. In addition, we analyzed the effect of dopamine-related genes polymorphism on the ability to decode the mental state of another, and searched for different genetic signatures. Our results show that overall, individuals with schizophrenia performed worse in the “Reading the Mind in the Eyes” (eyes) test, a simple well-defined task to infer the mental state of others than healthy individuals. Within the schizophrenia group, schizoaffective scored significantly higher than FE-SZ, SZ-CR, and healthy individuals. No difference was observed in performance between FE-SZ and SZ-CR subjects. Interestingly, FE-SZ and SZ-CR, but not schizoaffective individuals, performed worse in decoding negative and neutral emotional valance than the healthy control group. At the genetic level, we observed a significant effect of the DAT genotype, but not D4R genotype, on the eyes test performance. Our data suggest that understanding the mental state of another person is a trait marker of the illness, and might serve as an intermediate phenotype in the diagnostic process of schizophrenia disorders, and raise the possibility that DA-related DAT gene might have a role in decoding the mental state of another person.
机译：归因于精神状态（例如，他人的思想，信念和意图）的能力不足是精神分裂症中社会认知功能受损的关键因素。在当前的研究中，我们比较了患有首发精神分裂症的人（FE-SZ）和表现出症状缓解的精神分裂症的人（SZ-CR）对健康人和分裂情感病人的精神状态进行解码的能力。此外，我们分析了多巴胺相关基因多态性对解码他人心理状态的能力的影响，并寻找了不同的遗传特征。我们的结果表明，总体而言，精神分裂症患者在“阅读眼睛的思想”（眼睛）测试中表现较差，这是一项简单的定义明确的任务，可以推断健康人的心理状态。在精神分裂症组中，情感分裂得分明显高于FE-SZ，SZ-CR和健康个体。 FE-SZ和SZ-CR受试者之间的表现没有差异。有趣的是，FE-SZ和SZ-CR而非分裂情感个体在解码负性和中性情绪价方面比健康对照组表现更差。在遗传学水平上，我们观察到DAT基因型对眼睛测试性能的影响显着，而D4R基因型则没有。我们的数据表明，了解他人的精神状态是疾病的特征标记，并且可能在精神分裂症疾病的诊断过程中充当中间表型，并增加了与DA相关的DAT基因可能在解码中发挥作用的可能性。另一个人的精神状态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号