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首页> 外文期刊>Orthopedic reviews. >Early Knee Osteoarthritis Management Should First Address Mechanical Joint Overload
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Early Knee Osteoarthritis Management Should First Address Mechanical Joint Overload

机译：早期膝骨关节炎治疗应首先解决机械关节超负荷

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Early knee osteoarthritis poses a therapeutic dilemma to the musculoskeletal clinician. Despite the recent interest in arthroscopic and injectable regenerative therapies intended to repair or restore a focal target such as cartilage, meniscus, or subchondral bone, none have been shown to slow disease progression. A likely cause of these disappointing treatment outcomes is the failure to address chronic and excessive loading of the knee joint. A growing body of evidence suggests that first-line therapies for early knee osteoarthritis should emphasize unloading the knee joint since any potential therapeutic benefit of regenerative therapies will likely be attenuated by excessive mechanical demand at the knee joint. Minimally invasive medical devices such as patient-specific interpositional implants and extracapsular joint unloading implants are currently in development to address this clinical need.Key words: joint loading, knee, osteoarthritis
机译：早期膝骨关节炎给肌肉骨骼临床医生带来了治疗上的难题。尽管最近对关节镜和可注射的再生疗法感兴趣，这些疗法旨在修复或恢复诸如软骨，半月板或软骨下骨的局灶性靶标，但尚未显示出能够减缓疾病进展的方法。这些令人失望的治疗结果的可能原因是无法解决膝关节的慢性和过度负荷。越来越多的证据表明，早期膝关节骨关节炎的一线疗法应着重于减轻膝关节负担，因为膝关节过度机械需求可能会削弱再生疗法的任何潜在治疗益处。目前正在开发微创医疗设备，例如患者专用的间置植入物和囊外关节外植入物，以解决这种临床需求。关键词：关节负荷，膝关节，骨关节炎

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