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首页> 外文期刊>Oncogene >Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways
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Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways

机译：转移的不同途径：可塑性依赖性和可塑性依赖性途径

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The cascade that culminates in macrometastases is thought to be mediated by phenotypic plasticity, including epithelial鈥搈esenchymal and mesenchymal鈥揺pithelial transitions (EMT and MET). Although there is substantial support for the role of EMT in driving cancer cell invasion and dissemination, much less is known about the importance of MET in the later steps of metastatic colonization. We created novel reporters, which integrate transcriptional and post-transcriptional regulation, to test whether MET is required for metastasis in multiple in vivo cancer models. In a model of carcinosarcoma, metastasis occurred via an MET-dependent pathway; however, in two prostate carcinoma models, metastatic colonization was MET independent. Our results provide evidence for both MET-dependent and MET-independent metastatic pathways.
机译：认为在宏观转移中达到顶点的级联是由表型可塑性介导的，包括上皮的“间充质和间充质”的上皮转化（EMT和MET）。尽管对EMT在驱动癌细胞侵袭和扩散中的作用有实质性支持，但人们对于MET在转移定植的后续步骤中的重要性知之甚少。我们创建了新颖的报道分子，整合了转录和转录后调控，以测试MET是否需要在多种体内癌症模型中进行转移。在癌肉瘤的模型中，转移是通过MET依赖的途径发生的。然而，在两个前列腺癌模型中，转移性定植与MET无关。我们的结果为MET依赖和MET独立的转移途径提供了证据。

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