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首页> 外文期刊>Oncogene >Gene profiling reveals specific oncogenic mechanisms and signaling pathways in oncocytic and papillary thyroid carcinoma
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Gene profiling reveals specific oncogenic mechanisms and signaling pathways in oncocytic and papillary thyroid carcinoma

机译：基因分析揭示了甲状腺癌和乳头状癌的特定致癌机制和信号通路

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The oncogenic pathways in mitochondrial-rich thyroid carcinomas are not clearly understood. To investigate the possible implication of mitochondrial abundance in the genesis of thyroid tumors, we have explored the gene expression profile of six oncocytic carcinomas and six mitochondrial-rich papillary carcinomas using cDNA-microarray technology. A supervised approach allowed us to identify 83 genes differentially expressed in the two types of carcinoma. These genes were classified according to their ontologic profiles. Three genes, NOS3, alpha-actinin-2 and alpha-catenin, suspected of playing a role in tumor genesis, were explored by quantitative RT–PCR analysis and immunohistochemistry. Of the 59 genes overexpressed in papillary carcinomas, 51% were involved in cell communication. Of the 24 genes overexpressed in oncocytic carcinomas, 84% were involved in mitochondrial and cellular metabolism. Our results suggest that mitochondrial respiratory chain complexes III and IV play a significant role in the regulation of reactive oxygen species production by oncocytic tumors.
机译：线粒体丰富的甲状腺癌的致癌途径尚不清楚。为了研究线粒体丰度在甲状腺肿瘤发生中的可能意义，我们使用cDNA微阵列技术探索了六种包涵体癌和六种富含线粒体的乳头状癌的基因表达谱。一种有监督的方法使我们能够鉴定在两种类型的癌症中差异表达的83个基因。这些基因根据它们的本体特征进行分类。通过定量RT-PCR分析和免疫组织化学研究了怀疑在肿瘤发生中起作用的三个基因NOS3，α-actinin-2和α-catenin。在乳头状癌中过表达的59个基因中，有51％参与了细胞通讯。在粒细胞癌中过表达的24个基因中，有84％参与线粒体和细胞代谢。我们的结果表明，线粒体呼吸链复合物III和IV在调节肿瘤细胞产生的活性氧方面起着重要作用。

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