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首页> 外文期刊>Schizophrenia research and treatment >Ultrastructural Alterations of Myelinated Fibers and Oligodendrocytes in the Prefrontal Cortex in Schizophrenia: A Postmortem Morphometric Study
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Ultrastructural Alterations of Myelinated Fibers and Oligodendrocytes in the Prefrontal Cortex in Schizophrenia: A Postmortem Morphometric Study

机译：精神分裂症前额叶皮层中有髓纤维和少突胶质细胞的超微结构改变：事后形态计量学研究

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Schizophrenia is believed to result from altered neuronal connectivity and impaired myelination. However, there are few direct evidence for myelin abnormalities in schizophrenia. We performed electron microscopic study of myelinated fibers and oligodendrocytes and morphometric study of myelinated fibers in the prefrontal cortex in gray and white matters in schizophrenia and normal controls. Six types of abnormal fibers and ultrastructural alterations of oligodendrocytes were found in schizophrenia. No significant group differences in area density of myelinated fibers were found. Frequency of pathological fibers was increased significantly in gray matter in young and elderly schizophrenia patients and in patients with predominantly positive symptoms. In contrast, in white matter, frequency of altered fibers was increased significantly in elderly patients, in patients with predominantly negative symptoms, and correlated with illness duration. Progressive alterations of myelinated fibers in white matter might be followed by alterations of myelinated fibers in gray matter in schizophrenia.
机译：精神分裂症被认为是由于神经元连接性改变和髓鞘受损引起的。但是，很少有直接证据表明精神分裂症的髓磷脂异常。我们对精神分裂症和正常对照者的灰色和白色物质的前额叶皮层中的髓鞘纤维和少突胶质细胞进行了电子显微镜研究，并对髓鞘纤维的形态进行了研究。在精神分裂症中发现了六种类型的异常纤维和少突胶质细胞的超微结构改变。没有发现有髓纤维面积密度的显着组差异。青年和老年精神分裂症患者以及以阳性症状为主的患者的灰质中，病理纤维的频率显着增加。相反，在白质中，老年患者，主要为阴性症状的患者中纤维改变的频率显着增加，并且与疾病持续时间相关。在精神分裂症中，白质中髓鞘纤维的逐渐改变可能继之以灰质中髓鞘纤维的改变。

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