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Progesterone and Cerebral Function during Emotion Processing in Men and Women with Schizophrenia

机译：男性和女性精神分裂症患者情绪加工过程中的孕酮和脑功能

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Schizophrenia has been associated with disturbed levels of sex-steroid hormones, including estrogen and testosterone. In the present study we have examined the implication of a less studied hormone progesterone. Forty-three patients with schizophrenia (21 women) and 43 control participants (21 women) underwent functional MRI while viewing emotionally positive, negative, and neutral images. Blood samples were taken prior to the scanning session to evaluate progesterone levels. Simple regression analyses between levels of progesterone and brain activations associated with emotion processing were performed using SPM5. A positive correlation was found between progesterone levels and brain activations during processing of emotionally charged images in both healthy and schizophrenia men, but no significant relationship was revealed in women. These preliminary results indicate that progesterone is significantly associated with brain activations during processing of positive and negative affect in healthy and schizophrenia men, but not in women. Further investigation is warranted.
机译：精神分裂症与包括雌激素和睾丸激素在内的性类固醇激素水平紊乱有关。在本研究中，我们已经检查了较少研究的激素孕酮的含义。四十三名精神分裂症患者（21名女性）和43名对照参与者（21名女性）接受了功能性MRI检查，同时观察了情绪阳性，阴性和中性的图像。在扫描前采集血样以评估孕酮水平。使用SPM5对孕酮水平和与情绪处理相关的大脑激活之间的简单回归分析。在健康人和精神分裂症患者中，在处理带电图像时，孕酮水平与大脑激活之间存在正相关，但在女性中未发现显着相关。这些初步结果表明，在健康和精神分裂症的男性中，孕酮与正向和负向影响的过程中的大脑激活显着相关，而女性则没有。有必要进一步调查。

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