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首页> 外文期刊>Schizophrenia research and treatment >The PPARαAgonist Fenofibrate Reduces Prepulse InhibitionDisruption in a Neurodevelopmental Model of Schizophrenia
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The PPARαAgonist Fenofibrate Reduces Prepulse InhibitionDisruption in a Neurodevelopmental Model of Schizophrenia

机译：PPARα激动剂非诺贝特减少精神分裂症神经发育模型中的脉冲前抑制破坏。

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Oxidative stress has been implicated in neurodevelopmental theories of schizophrenia. Antioxidant Peroxysome Proliferator-Activated Receptorsα(PPARα) agonist fenofibrate has neuroprotective properties and could reverse early preclinical infringements that could trigger the illness. We have evaluated the neuroprotective interest of fenofibrate in a neurodevelopmental rat model of schizophrenia. The oxidative lesion induced by Kainic Acid (KA) injection at postnatal day (PND) 7 has previously been reported to disrupt Prepulse Inhibition (PPI) at PND56 but not at PND35. In 4 groups of 15 male rats each, KN (KA-PND7+normal postweaning food), KF (KA-PND7+fenofibrate 0.2% food), ON (saline-PND7+normal food), and OF (saline+fenofibrate food), PPI was recorded at PND35 and PND56. Three levels of prepulse were used: 73 dB, 76 dB, and 82 dB for a pulse at 120 dB. Four PPI scores were analyzed: PPI73, PPI76, PPI82, and mean PPI (PPIm). Two-way ANOVAs were used to evaluate the effects of both factors (KA+fenofibrate), and, in case of significant results, intergroup Student’st-tests were performed. We notably found a significant difference (P<0.05) in PPIm between groups KN and KF at PND56, which supposes that fenofibrate could be worthy of interest for early neuroprotection in schizophrenia.
机译：氧化应激与精神分裂症的神经发育理论有关。抗氧化剂过氧化物酶体增殖物激活受体α（PPARα）激动剂非诺贝特具有神经保护作用，可以逆转可能触发该病的早期临床前侵害。我们已经评估了非诺贝特在精神分裂症神经发育大鼠模型中的神经保护作用。以前有报道称，在产后一天（PND）7时，通过Kaineic Acid（KA）注射诱导的氧化损伤会破坏PND56处的脉冲前抑制（PPI），而不会破坏PND35处。在4组中，每组15只雄性大鼠，分别是KN（KA-PND7 +正常断奶后食物），KF（KA-PND7 +非诺贝特0.2％食物），ON（盐水-PND7 +正常食物）和OF（盐+非诺贝特食物） ，PPI记录在PND35和PND56处。使用了三个级别的预脉冲：对于120 dB的脉冲，分别为73 dB，76 dB和82 dB。分析了四个PPI得分：PPI73，PPI76，PPI82和平均PPI（PPIm）。使用双向方差分析（ANOVA）来评估两个因素（KA +非诺贝特）的影响，如果结果显着，则进行组间学生st检验。我们特别发现在PND56时，KN组和KF组之间的PPIm存在显着差异（P <0.05），这表明非诺贝特对于精神分裂症的早期神经保护可能值得关注。

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