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首页> 外文期刊>Scars, Burns & Healing >The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: a systematic review:
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The effects of advanced glycation end products (AGEs) on dermal wound healing and scar formation: a systematic review:

机译：晚期糖基化终产物（AGEs）对皮肤伤口愈合和疤痕形成的影响：系统评价：

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Introduction:With ageing, the skin gradually loses its youthful appearance and functions like wound healing and scar formation. The pathophysiological theory of Advanced Glycation End products (AGEs) has gained traction during the last decade. This review aims to document the influence of AGEs on the mechanical and physiologic properties of the skin, how they affect dermal wound healing and scar formation in high-AGE populations like elderly patients and diabetics, and potential therapeutic strategies.Methods:This systematic literature study involved a structured search in Pubmed and Web of Science with qualitative analysis of 14 articles after a three-staged selection process with the use of in- and exclusion criteria.Results:Overall, AGEs cause shortened, thinned, and disorganized collagen fibrils, consequently reducing elasticity and skin/scar thickness with increased contraction and delayed wound closure. Documented therapeutic strategies include dietary AGE restriction, sRAGE decoy receptors, aminogu...
机译：简介：随着年龄的增长，皮肤会逐渐失去其年轻的外观，并具有诸如伤口愈合和疤痕形成的功能。在过去的十年中，高级糖化终产物（AGEs）的病理生理学理论得到了关注。这篇综述旨在记录AGEs对皮肤机械和生理特性的影响，它们如何影响老年患者和糖尿病患者等高AGE人群的皮肤伤口愈合和疤痕形成以及潜在的治疗策略。涉及在Pubmed和Web of Science中进行结构化搜索，对三个阶段的选择过程进行了定性分析，并采用了入选和排除标准。结果：总体而言，AGEs导致胶原蛋白纤维变短，变薄和混乱，从而减少了胶原蛋白原纤维的形成。弹性和皮肤/疤痕厚度增加收缩和延迟伤口闭合。记录在案的治疗策略包括饮食AGE限制，sRAGE诱饵受体，氨基...

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