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首页> 外文期刊>Sao Paulo Medical Journal >Enhancement of liver size by stimulation of intact rat liver with exogenous hepatotrophic factors
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Enhancement of liver size by stimulation of intact rat liver with exogenous hepatotrophic factors

机译：通过外源性肝营养因子刺激完整大鼠肝脏来增强肝脏大小

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In mammals, liver size is related to animal body weight at the 2.5 to 3% proportion, a ratio mediated by the afflux of hepatotrophic factors. Formulas capable of modifying this ratio have been developed in previous studies on the rat, with enhancement of liver size brought about by intraperitoneal (portal) infusion of exogenous factors such as glucose, amino acids, insulin, glucagon, vitamins, electrolytes, and triiodothyronine. However, the efficacy of these formulations was accompanied by increased animal mortality (PARRA et al.19,20 ). The present study, which was carried out with small methodological modifications on a larger number of rats using daily intraperitoneal injections of a solution of exogenous hepatotrophic factors (40 ml/kg) for seven days, confirms the previous findings, with a 114.16 ± 7.90% enhancement of liver size beyond the expected value for the body weight of the animal. However, the problem of animal mortality was not fully resolved.
机译：在哺乳动物中，肝脏的大小与动物体重的比例为2.5％至3％，该比例由肝营养因子的外流介导。在先前的大鼠研究中，已经开发出能够改变该比例的配方，并通过腹膜内（门户）输注葡萄糖，氨基酸，胰岛素，胰高血糖素，维生素，电解质和三碘甲腺氨酸等外源性因素来增加肝脏的大小。然而，这些制剂的功效伴随着动物死亡率的增加（PARRA等19,20）。本研究是通过每天腹膜内注射外源性肝营养因子（40 ml / kg）溶液持续7天，对大量大鼠进行小的方法学修改而进行的，证实了先前的发现，为114.16±7.90％肝脏大小的增加超出了动物体重的预期值。但是，动物死亡率的问题尚未完全解决。

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