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首页> 外文期刊>Sao Paulo Medical Journal >Ethiological treatment of acute and chronic Chagas' heart disease
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Ethiological treatment of acute and chronic Chagas' heart disease

机译：急慢性查加斯心脏病的Ethioologic治疗

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The uncertaintties in the ethiological treatment of Chagas' Disease are consequence of the lack of entire knowledge of its pathogeny and the no existence of a healing criterium. There is a consensus that antiparasite drugs should be used in the acute phase of the infection, regardless of the infection route, in new crisis, in patients under immunossuppression and in organs transplantation. There is still controversy regarding subacute, chronic or indetermined phase or cases with mild cardiac/digestive forms, not included in the situations listed above neither in a research protocol. The treatment includes oral benzonidazol 5 mg/kg/day, bid or tid for 60 days. In 71 patients monitored in this fashion, the authors have found 60% of negative xenodiagnostic at the end of treatment. It is still necessary, however, to continue to investigate and accomplishing more randomized trials to confirm the efficacy of such method, and also to try to obtain effective and less toxic agents. It is also fundamental to standardize a more reliable healing criterium.
机译：恰加斯氏病的病因学治疗方法的不确定性是由于缺乏对其致病性的全面了解以及不存在治愈标准所致。人们普遍认为，无论感染途径如何，在新的危机中，免疫抑制患者和器官移植患者中，都应在感染的急性期使用抗寄生虫药物。关于亚急性，慢性或不确定期或轻度心脏/消化形式的病例仍存在争议，研究方案中也未包括上述情况。治疗方法包括口服苯甲达唑5 mg / kg /天，每日两次或每日两次，持续60天。在以这种方式监测的71名患者中，作者发现治疗结束时60％的异种诊断为阴性。但是，仍然有必要继续研究并完成更多的随机试验，以确认这种方法的有效性，并试图获得有效且毒性较小的药物。标准化更可靠的治疗标准也是至关重要的。

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