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首页> 外文期刊>Sao Paulo Medical Journal >Anti-Toxoplasma gondii antibodies in pregnant women and their newborn infants in the region of S?o José do Rio Preto, S?o Paulo, Brazil
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Anti-Toxoplasma gondii antibodies in pregnant women and their newborn infants in the region of S?o José do Rio Preto, S?o Paulo, Brazil

机译：巴西圣保罗圣何塞杜里约普雷图地区孕妇和新生儿的弓形虫抗体

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CONTEXT AND OBJECTIVE: Toxoplasmosis transmission during pregnancy can cause severe sequelae in fetuses and newborns. Maternal antibodies may be indicators of risk or immunity. The aim here was to evaluate seropositivity for anti-Toxoplasma gondii (anti-T. gondii) immunoglobulin M (IgM) and immunoglobulin G (IgG) antibodies and IgG avidity in pregnant women and their newborn infants. DESIGN AND SETTING: Cross-sectional study in a high-risk pregnancy outpatient clinic. METHODS: Serum samples from pregnant women (n = 87) and their respective newborns (n = 87) were evaluated for anti-T. gondii antibodies using indirect immunofluorescence (IIF) (IgM and IgG), enzyme-linked immunosorbent assay (ELISA) (IgG) and an avidity test. RESULTS: Anti-T. gondii antibodies were identified in 64.4% of the serum samples from the mothers and their infants (56/87). Except for two maternal serum samples (2.3%), all others were negative for anti-T. gondii IgM antibodies, using IIF. The results showed that 92.9% of the pregnant women had high IgG avidity indexes (> 30%) and four samples had avidity indexes between 16 and 30%. Two women in the third trimester of pregnancy were positive for anti-T. gondii IgM antibodies; their babies had avidity indexes between 16 and 30%. The avidity indexes of serum from the other 83 newborns were similar to the results from their mothers. CONCLUSIONS: The results showed that 2% of the pregnant women were at risk of T. gondii transmission during the gestational period. These data seem to reflect the real situation of gestational toxoplasmosis in the northwestern region of the state of S?o Paulo.
机译：背景与目的：妊娠期间的弓形虫病传播可导致胎儿和新生儿严重后遗症。母体抗体可能是风险或免疫力的指标。此处的目的是评估孕妇及其新生儿对弓形虫（抗弓形虫）免疫球蛋白M（IgM）和免疫球蛋白G（IgG）抗体的血清阳性，以及IgG亲和力。设计与地点：在高危妊娠门诊中进行的横断面研究。方法：评估了孕妇（n = 87）及其新生儿（n = 87）的血清样本中的抗-T水平。使用间接免疫荧光（IIF）（IgM和IgG），酶联免疫吸附测定（ELISA）（IgG）和亲和力测试的刚迪抗体。结果：抗T。在母亲和婴儿的血清样本中，有64.4％检出了弓形虫抗体（56/87）。除两个孕妇血清样品（2.3％）外，其他所有抗体均呈阴性。 gondii IgM抗体，使用IIF。结果显示，92.9％的孕妇具有较高的IgG亲和力指数（> 30％），四个样本的亲和力指数在16％至30％之间。妊娠中期三个妇女的抗T抗体阳性。刚地IgM抗体;他们的婴儿的亲和力指数在16％到30％之间。其他83个新生儿的血清亲和力指数与母亲的相似。结论：结果表明，在妊娠期有2％的孕妇有弓形虫传播的风险。这些数据似乎反映了圣保罗州西北地区妊娠弓形虫病的真实情况。

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