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首页> 外文期刊>Sao Paulo Medical Journal >Efficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review
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Efficacy in treatment of subclinical cervical HPV infection without intraepithelial neoplasia: systematic review

机译：治疗亚临床宫颈HPV感染而无上皮内瘤变的疗效：系统评价

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CONTEXT: The treatment of the subclinical Human papillomavirus (HPV) infection of the uterine cervix is controversial. OBJECTIVE: To assess the efficacy of any therapy for subclinical HPV infection of the cervix without intraepithelial neoplasia, via a search in the medical literature. METHOD: We performed a systematic review with a comprehensive reference search in Medline, LILACS, Excerpta Medica, AIDSLINE, Popline, Cochrane Library and other authors' reference lists to identify experimental studies of therapy for subclinical HPV infection without intraepithelial neoplasia of the uterine cervix. In order to identify unpublished studies, we also contacted experts in the area, clinical trial registries, pharmaceutical industries, government and research institutions. We also searched on the Internet and in the book-of-abstracts of some medical conferences. The studies identified were masked and selected by inclusion criteria to help ascertain their internal validity. The data about regression or progression of HPV infection were extracted from the studies included. RESULTS: We identified 67 studies related to the treatment of subclinical HPV infection without intraepithelial neoplasia of the uterine cervix. Only five clinical trials matched the inclusion criteria and none demonstrated significant differences between the experimental group and the control group concerning regression of HPV infection (with or without CIN I) or progression to higher grades of CIN. CONCLUSION: The evidence we found in the medical literature regarding the efficacy of any therapy for subclinical HPV infection without intraepithelial neoplasia of the uterine cervix was unsatisfactory.
机译：背景：宫颈癌的亚临床人类乳头瘤病毒（HPV）感染的治疗尚存争议。目的：通过在医学文献中进行搜索，评估任何疗法对子宫颈亚临床HPV感染而无上皮内瘤变的疗效。方法：我们在Medline，LILACS，Excerpta Medica，AIDSLINE，Popline，Cochrane Library和其他作者的参考文献清单中进行了全面的参考检索，以鉴定针对亚临床HPV感染而无宫颈上皮内瘤变的疗法的实验研究。为了确定未发表的研究，我们还联系了该领域，临床试验注册机构，制药行业，政府和研究机构的专家。我们还在互联网和某些医学会议的摘要中进行了搜索。对所鉴定的研究进行掩盖，并根据纳入标准进行选择，以帮助确定其内部有效性。从包括在内的研究中提取有关HPV感染消退或进展的数据。结果：我们确定了67项与亚临床型HPV感染治疗相关的，无宫颈上皮内瘤变的研究。只有五项临床试验符合纳入标准，没有一项表明实验组和对照组在HPV感染消退（有或没有CIN I）或进展为更高的CIN方面有显着差异。结论：我们在医学文献中发现的证据表明，任何治疗亚临床型HPV感染而无子宫颈上皮内瘤变的疗效均不能令人满意。

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