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首页> 外文期刊>Sao Paulo Medical Journal >Gestational prognostic factors in women with recurrent spontaneous abortion
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Gestational prognostic factors in women with recurrent spontaneous abortion

机译：反复自然流产妇女的妊娠预后因素

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CONTEXT AND OBJECTIVE: Recurrent spontaneous abortion (RSA) is defined as three or more consecutive pregnancy losses before 20 weeks and is associated with several etiological factors related to genetics, anatomy, hormones, infections and immunology, for example. Many cases of RSA remain unclear. New factors or their associations may influence gestational results. The aim was to identify possible single or associated causes of RSA that could predict gestational prognosis for women undergoing investigation and treatment. DESIGN AND SETTING: Case-control study, at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp). METHODS: Two hundred and forty-six medical records of women with RSA seen at the Recurrent Abortion Outpatient Clinic, Department of Obstetrics and Gynecology School of Medicine, Universidade Estadual de Campinas (Unicamp), between 1994 and 2003, were evaluated. Data on age, obstetric history, possible etiological factors, treatment and pregnancy outcomes were evaluated. Statistical analysis was performed using odds ratios (OR), logistic regression analysis and decision trees. RESULTS: Two hundred and twenty-nine women were included in the study. The most frequently found etiological factors were immunological, particularly alloimmune factors (93.9%). Women with a single alloimmune factor had better gestational results (77.7% deliveries) than those with other associated factors. Autoimmune factors were associated with a higher abortion rate (OR: 4.30; 95% confidence interval, CI: 1.36-13.63). No association was found between the number of abortions prior to treatment and pregnancy results. Women aged 40 or over presented the highest rate of spontaneous abortion (OR: 5.83; 95% CI: 1.12-30.40). CONCLUSION: Age over 40 years old, immunological factors and two or more concomitant factors were associated with poor gestational outcomes among the women studied.
机译：背景与目的：反复自然流产（RSA）定义为20周前连续3次或更多次连续流产，并且与一些与遗传学，解剖学，激素，感染和免疫学相关的病因相关。 RSA的许多情况仍不清楚。新因素或其关联可能会影响妊娠结果。目的是确定可能导致RSA的单一或相关原因，这些原因可以预测接受调查和治疗的妇女的妊娠预后。设计与地点：坎帕纳斯大学医学院妇产科医学院流产复发流产门诊病例对照研究。方法：对1994年至2003年间在坎帕纳斯大学医学院妇产科医学院复发流产门诊就诊的246例RSA女性患者的病历进行了评估。评估了年龄，产科史，可能的病因，治疗和妊娠结局的数据。使用比值比（OR），逻辑回归分析和决策树进行统计分析。结果：229名妇女被纳入研究。最常见的病因是免疫学因素，尤其是同种免疫因素（93.9％）。具有单一同种免疫因子的妇女的妊娠结果（分娩率为77.7％）比具有其他相关因素的妇女更好。自身免疫因素与更高的流产率相关（OR：4.30; 95％置信区间，CI：1.36-13.63）。治疗前的流产次数与妊娠结果之间没有关联。 40岁或以上的女性自然流产率最高（OR：5.83; 95％CI：1.12-30.40）。结论：年龄在40岁以上的妇女中，免疫因素和两个或多个伴随因素与不良的妊娠结局有关。

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