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首页> 外文期刊>Sao Paulo Medical Journal >Prognosis for patients diagnosed with pregnancy-associated breast cancer: a paired case-control study
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Prognosis for patients diagnosed with pregnancy-associated breast cancer: a paired case-control study

机译：妊娠相关乳腺癌患者的预后：配对病例对照研究

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CONTEXT AND OBJECTIVE: Previous studies have suggested that the occurrence of pregnancy concomitantly with a diagnosis of breast cancer may affect the evolution of the neoplasia. The present study aimed to compare pregnancy-associated breast cancer (PABC) patients with non-pregnant cancer patients (controls) in relation to the time taken to diagnose the disease, tumor characteristics and mortality. DESIGN AND SETTING: A retrospective, paired case-control study was conducted at the Hospital da Santa Casa de Misericórdia and Centro de Quimioterapia Antiblástica e Imunoterapia in Belo Horizonte, Brazil. METHODS: The study involved 87 PABC and 252 control patients. The influence of covariables (interval between first symptoms and diagnosis, tumor histology, size of primary tumor, distant metastasis, grade of malignancy, hormone receptor status and axillary lymph node involvement) and the pregnancy variable on overall survival was investigated using univariate and multivariate analyses. RESULTS: The median overall survival for PABC patients of 30.1 months (95% confidence interval, CI: 19.4-40.9 months) was significantly different (P = 0.005) from that of the control group (53.1 months; 95% CI: 35.1-71.0 months). The cumulative overall survivals after five and ten years were, respectively, 29.7 and 19.2% for PABC patients, and 47.3 and 34.8% for control patients (P = 0.005). Tumor size, grade of malignancy, distant metastasis and pregnancy were independent factors that significantly modified disease prognosis. CONCLUSIONS: Pregnancy was an independent prognostic factor. The overall survival of PABC patients was shorter than that of non-pregnant patients.
机译：背景与目的：先前的研究表明，妊娠的发生与乳腺癌的诊断可能会影响肿瘤的发展。本研究旨在比较与妊娠相关的乳腺癌（PABC）患者与未妊娠的癌症患者（对照）在诊断疾病，肿瘤特征和死亡率方面所花费的时间。设计与地点：在巴西贝洛哈里桑塔的圣卡萨德米西里科迪亚医院和基米奥特拉皮安防盲肠医院进行了一项回顾性配对病例对照研究。方法：该研究涉及87名PABC和252名对照患者。使用单因素和多因素分析研究了协变量（初次症状和诊断的间隔，肿瘤组织学，原发肿瘤的大小，远处转移，恶性程度，激素受体状态和腋窝淋巴结受累）和妊娠变量对总体生存率的影响。 。结果：PABC患者的中位总生存期为30.1个月（95％置信区间，CI：19.4-40.9个月）与对照组（53.1个月; 95％CI：35.1-71.0）相比有显着差异（P = 0.005）。个月）。五年和十年后，PABC患者的累积总生存率分别为29.7％和19.2％，对照患者为47.3和34.8％（P = 0.005）。肿瘤大小，恶性程度，远处转移和妊娠是显着改变疾病预后的独立因素。结论：妊娠是独立的预后因素。 PABC患者的总生存期短于未怀孕患者。

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