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首页> 外文期刊>Sao Paulo Medical Journal >Synchronous thyroid and colon metastases from epidermoid carcinoma of the lung: case report
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Synchronous thyroid and colon metastases from epidermoid carcinoma of the lung: case report

机译：肺表皮样癌的同步甲状腺和结肠转移：病例报告

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CONTEXT: Non-small cell lung cancer (NSCLC) progresses to distant metastases in most cases. The most frequent sites for distant metastases are the bones, central nervous system, adrenal glands and liver. Dissemination to the skin, myocardium, thyroid gland and intestine may occur, but is rare. CASE REPORT: We describe a case of squamous cell carcinoma in the lungs, with metastases in the colon and thyroid, in a 66-year-old female patient. The lesion was unresectable and chemotherapy was started. The patient evolved with intestinal subocclusion, and colonoscopy showed the presence of a polyp. Biopsy and immunohistochemical analysis on the polyp showed that it was compatible with squamous cell carcinoma of pulmonary origin. At a follow-up consultation, the patient presented a thyroid nodule. A aspiration biopsy and cellblock immunohistochemistry confirmed the squamous cell carcinoma of pulmonary origin. After third-line chemotherapy, the patient progressed with acute obstructive abdomen due to a retroperitoneal mass. She underwent exploratory laparotomy and died due to surgical complications. Metastases to the thyroid and colon are rarely reported in cases of epidermoid carcinoma of the lungs. Gastrointestinal involvement in pulmonary metastases may affect the stomach, small intestine and colon, and cases of bleeding and perforation have already been reported. Although richly vascularized, the thyroid is an infrequent site for metastases. Such sites reflect poor prognoses for the clinical evolution. We did not find any previous reports in the literature, on lung cancer with metastases concomitantly in the colon and thyroid, in a single patient.
机译：背景：在大多数情况下，非小细胞肺癌（NSCLC）会发展为远处转移。远处转移的最常见部位是骨骼，中枢神经系统，肾上腺和肝脏。可能发生向皮肤，心肌，甲状腺和肠道的传播，但很少见。病例报告：我们描述了一位66岁女性患者的肺部鳞状细胞癌病例，其中结肠和甲状腺转移。病灶无法切除，开始化疗。患者逐渐发展为肠下阻塞，结肠镜检查显示存在息肉。息肉的活检和免疫组织化学分析表明，它与肺源性鳞状细胞癌相容。在随访中，患者出现了甲状腺结节。穿刺活检和细胞阻断免疫组织化学证实了肺源性鳞状细胞癌。三线化疗后，由于腹膜后肿块，患者进展为急性阻塞性腹部。她接受了探索性剖腹手术，并因手术并发症死亡。在肺表皮样癌的病例中，很少有甲状腺和结肠转移的报道。胃肠道参与肺转移可能会影响胃，小肠和结肠，并且已经有出血和穿孔的病例报道。尽管血管丰富，但甲状腺很少发生转移。这些部位反映出临床发展的不良预后。在文献中，我们没有发现任何有关单个患者同时伴随结肠和甲状腺转移的肺癌的报道。

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