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首页> 外文期刊>Sao Paulo Medical Journal >Frequencies of interleukin-6, GST and progesterone receptor gene polymorphisms in postmenopausal women with low bone mineral density
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Frequencies of interleukin-6, GST and progesterone receptor gene polymorphisms in postmenopausal women with low bone mineral density

机译：骨密度低的绝经后妇女白细胞介素6，谷胱甘肽转氨酶（GST）和孕激素受体基因多态性的频率

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CONTEXT AND OBJECTIVE: Osteoporosis is a skeletal disorder characterized by low bone mineral density (BMD). Studies have shown that some of the genetic components relating to lower BMD may be detected by polymorphisms. Our aim was to evaluate the frequencies of interleukin-6, GST and progesterone receptor gene polymorphisms in postmenopausal women with low BMD. DESIGN AND SETTING: Cross-sectional study, conducted in a public university in São Paulo, Brazil. METHODS : We evaluated interleukin-6 (IL-6), progesterone receptor gene (PROGINS) and glutathione S-transferase (GST) polymorphisms in 110 postmenopausal women with no previous use of hormone therapy. Tests were performed using DNA-PCR, from oral scrapings. We used Student's t-test and a logistic regression model for statistical analysis. RESULTS : Regarding IL-6 polymorphism, 58.2% of the patients were homozygotes (GG) and 41.8% had allele C (heterozygote or mutant homozygote + GC or CC). PROGINS genotype polymorphism was absent in 79% (wild homozygote or P1/P1) and present in 20.9% (heterozygote or P1/P2). Regarding GSTM1 polymorphism, the allele (1/1) was present in 72.7% of the patients and was absent in 27.3%. We found that IL-6 polymorphism had statistically significant correlations with the L2-L4 T-score (P = 0.032) and with BMD (P = 0.005). Women with IL-6 polymorphism were 2.3 times more likely to have a L2-L4 T-score of less than -1, compared with those not presenting this polymorphism. CONCLUSION: IL-6 gene polymorphism was correlated with low BMD, whereas the PROGINS and GSTM1 polymorphisms did not show any correlation.
机译：背景与目的：骨质疏松症是一种以骨矿物质密度低（BMD）为特征的骨骼疾病。研究表明，一些与较低骨密度有关的遗传成分可能通过多态性检测到。我们的目的是评估低BMD绝经后妇女白细胞介素6，GST和孕激素受体基因多态性的频率。设计与环境：横断面研究在巴西圣保罗的一所公立大学进行。方法：我们评估了110名绝经前未使​​用激素治疗的妇女的白细胞介素6（IL-6），孕激素受体基因（PROGINS）和谷胱甘肽S-转移酶（GST）多态性。使用DNA-PCR从口腔刮取物中进行测试。我们使用学生t检验和逻辑回归模型进行统计分析。结果：关于IL-6多态性，58.2％的患者为纯合子（GG），41.8％的患者为等位基因C（杂合子或突变纯合子+ GC或CC）。 PROGINS基因型多态性在79％（野生纯合子或P1 / P1）中不存在，而在20.9％（杂合子或P1 / P2）中存在。关于GSTM1多态性，等位基因（1/1）在72.7％的患者中存在，而在27.3％的患者中不存在。我们发现IL-6多态性与L2-L4 T评分（P = 0.032）和BMD（P = 0.005）具有统计学上的显着相关性。与未表现出这种多态性的女性相比，具有IL-6多态性的女性的L2-L4 T得分低于-1的可能性高2.3倍。结论：IL-6基因多态性与低骨密度有关，而PROGINS和GSTM1多态性无相关性。

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