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首页> 外文期刊>Sao Paulo Medical Journal >What do Cochrane systematic reviews say about interventions for vitamin D supplementation?
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What do Cochrane systematic reviews say about interventions for vitamin D supplementation?

机译：Cochrane系统评价对补充维生素D的干预措施有何评论？

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ABSTRACT CONTEXT AND OBJECTIVE: Despite the high prevalence of vitamin D supplementation, its use remains controversial. The objective of this review was to identify and summarize the evidence from Cochrane systematic reviews regarding vitamin D supplementation for preventing ortreating any clinical condition. DESIGN AND SETTING: Review of systematic reviews, conducted in the Discipline of Evidence-Based Medicine, Escola Paulista de Medicina, Universidade Federal de S?o Paulo. METHODS: A search was conducted to identify all Cochrane systematic reviews that fulfilled the inclusion criteria. Titles and abstracts were screened by two authors. RESULTS: We included 27 Cochrane systematic reviews: 10 assessing use of vitamin D for prevention and 17 for treatment. The reviews found moderate to high quality of evidence regarding the benefit of vitamin D for pregnant women (prevention of adverse events: preterm birth risk [rate ratio, RR 0.36; 95% confidence interval, CI 0.14 to 0.93] and low birthweight risk [RR 0.40; 95% CI 0.24 to 0.67]) and for asthma patients (reduction of severe exacerbations [RR 0.63; 95% CI 0.45 to 0.88]). No benefit was found regarding vitamin D supplementation alone (without calcium) for preventing hip or any new fracture. For all other outcomes assessed under various conditions, the current quality of evidence is low or unknown, and therefore insufficient for any recommendation. CONCLUSION: Based on moderate to high quality of evidence, the Cochrane systematic reviews included here showed that there were some benefits from vitamin D supplementation for pregnant women and asthma patients and no benefits for preventing fractures.
机译：摘要背景和目的：尽管维生素D补充剂的使用率很高，但其使用仍存在争议。这篇综述的目的是鉴定和总结来自Cochrane系统综述关于补充维生素D预防或治疗任何临床疾病的证据。设计与环境：系统评价的回顾，在圣保罗联邦大学的循证医学学科Escola Paulista de Medicina进行。方法：进行搜索以鉴定所有符合纳入标准的Cochrane系统评价。标题和摘要由两名作者筛选。结果：我们纳入了27项Cochrane系统评价，其中10项评价了维生素D的预防使用评估，17项是治疗的评估。审查发现有关维生素D对孕妇的益处的中等至高质量证据（预防不良事件：早产风险[发生率，RR 0.36; 95％置信区间，CI 0.14至0.93]和低出生体重风险[RR 0.40; 95％CI为0.24至0.67]）和哮喘患者（减轻严重加重[RR 0.63; 95％CI为0.45至0.88]）。没有发现单独补充维生素D（不含钙）可预防髋部或任何新骨折的益处。对于在各种条件下评估的所有其他结果，当前的证据质量较低或未知，因此不足以提出任何建议。结论：基于中等至高质量的证据，此处包括的Cochrane系统评价显示，维生素D补充剂对孕妇和哮喘患者有一定益处，而预防骨折没有益处。

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