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首页> 外文期刊>Sao Paulo Medical Journal >Schirrous invasive ductal carcinoma of the breast overexpress p53 oncoprotein
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Schirrous invasive ductal carcinoma of the breast overexpress p53 oncoprotein

机译：乳腺浸润性导管癌过表达p53癌蛋白

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CONTEXT: Breast cancer is the most important neoplasm in adult women, and its worldwide incidence is growing. The tumoral stroma is very important for modulating the growth and invasion of the tumor itself. The relationship between these two components is not completely understood. Schirrous carcinoma is a variant of ductal invasive carcinoma in which the stroma is very desmoplastic, and the importance of this finding still a motive for debate in the literature. OBJECTIVE: To compare the desmoplastic reactions against biological markers, such as estrogen and progesterone receptors, oncoprotein c-erbB-2 and oncoprotein p53, with the objective of studying the relationship between the tumoral stroma and epithelial cancer cells. TYPE OF STUDY: Retrospective study. SETTING: Cancer Hospital A C Camargo and Faculty of Medicine of Ribeir?o Preto, University of S?o Paulo, S?o Paulo, Brazil. SAMPLE: 107 adult women operated because of ductal invasive carcinoma. The cases were separated into 4 groups according to the desmoplastic reaction -- less than 15%, between 15-50%, 51-85%, and more than 85% fibrosis. The grade of fibrosis was determined by picrus-sirius staining and quantified by using a microscope with a stereo-imaging grid. Immunohistochemical methods were used to determine the expression of the hormonal receptors and c-erbB-2/p53 oncoprotein. MAIN MEASUREMENTS: Extent of desmoplastic reaction versus expression of estrogen and progesterone receptors, oncoprotein c-erbB-2, and oncoprotein p53. RESULTS: The results showed that schirrous carcinoma expresses oncoprotein p53 more frequently than other carcinomas with less extensive desmoplastic reaction. There were no differences between the grade of fibrosis and the other biological markers. CONCLUSION: The intense stromatous reaction in invasive ductal carcinoma may modulate the expression of p53. Further investigations should be made with the aim of understanding how this expression determines the proliferative activity in schirrous carcinoma, and whether this overexpression is secondary to mutation of the p53 gene or due to modulation of other molecules of the stroma.
机译：背景：乳腺癌是成年女性中最重要的肿瘤，其全球发病率正在上升。肿瘤基质对于调节肿瘤本身的生长和侵袭非常重要。这两个组件之间的关系尚未完全了解。 Schirrous癌是导管浸润性癌的一种变体，其中的间质非常增生，这一发现的重要性仍然是文献辩论的动机。目的：比较针对雌，孕激素受体，癌蛋白c-erbB-2和癌蛋白p53等生物学指标的去肿瘤反应，以研究肿瘤基质与上皮癌细胞之间的关系。研究类型：回顾性研究。地点：巴西圣保罗大学Ribeir？o Preto癌症研究中心卡马戈和医学院。样本：107名成年女性因导管浸润性癌而手术。根据增生反应将病例分为4组-少于15％，介于15-50％，51-85％和大于85％的纤维化。纤维化的程度通过皮库斯-西里乌斯染色确定，并通过使用带有立体成像网格的显微镜进行定量。免疫组织化学方法用于确定激素受体和c-erbB-2 / p53癌蛋白的表达。主要测量：增生反应程度与雌激素和孕激素受体，癌蛋白c-erbB-2和癌蛋白p53的表达之间的关系。结果：结果表明，鳞状癌表达的癌蛋白p53比其他癌具有更广泛的去增生反应。纤维化程度和其他生物学指标之间没有差异。结论：浸润性导管癌中强烈的基质反应可能调节p53的表达。应当进行进一步的研究，以了解该表达如何确定轮状癌的增殖活性，以及​​该过表达是继发于p53基因突变还是由于基质的其他分子的调控所致。

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