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Investigation of Anti-Toxocaraand Anti-ToxoplasmaAntibodies in Patients with Schizophrenia Disorder

机译:精神分裂症患者抗弓形虫和弓形虫抗体的研究

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Objective. The aim of the present study was to examine the relationship betweenToxoplasma gondiiandToxocaraspp. infections in patients with schizophrenia disorder.Method. A total of 100 patients with schizophrenia disorder and 95 healthy individuals participated in the study. Participants were tested for the presence of anti-T. gondiiand anti-Toxocaraspp. antibodies by ELISA and Western blotting. Data were analyzed using Chi-square test and Fisher9s exact test.Results. There were no differences inT. gondiiIgG seroprevalence between patients with schizophrenia and healthy individuals (P=0.1), but there were differences in seroprevalence between males and females with schizophrenia (P=0.009). In contrast,Toxocaraspp. IgG seroprevalence was greater in patients with schizophrenia disorder than in healthy individuals (P=0.02), but there were no differences in seroprevalence between men and women with schizophrenia (P=0.5). Finally, there were no differences in seroprevalence ofT. gondiiorToxocaraspp. IgG among different subtypes of schizophrenia, various age groups, residential area, or clinical course of treatment (P>0.05).Conclusion. The present study suggests that patients with schizophrenia disorder are at elevated risk ofToxocaraspp. infection. Moreover, contamination withT. gondiiis a risk factor for schizophrenia in women.
机译:目的。本研究的目的是检查弓形虫和弓形虫之间的关系。精神分裂症患者的感染共有100位精神分裂症患者和95位健康个体参加了研究。测试参与者的抗-T的存在。刚地和抗毒素。 ELISA和Western印迹检测抗体。数据采用卡方检验和Fisher9s精确检验进行分析。 T没有差异。精神分裂症患者和健康个体之间的弓形虫IgG血清阳性率(P = 0.1),但男性和女性精神分裂症患者的血清阳性率存在差异(P = 0.009)。相比之下,Toxocaraspp。精神分裂症患者的IgG血清阳性率高于健康个体(P = 0.02),但精神分裂症的男女之间血清阳性率无差异(P = 0.5)。最后,T的血清阳性率没有差异。贡迪奥·托克萨拉斯普。不同精神分裂症亚型,不同年龄段,居住地区或临床治疗过程中的IgG(P> 0.05)。本研究表明,精神分裂症患者的Toxocaraspp风险较高。感染。而且,T污染。刚地斯是女性精神分裂症的危险因素。

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