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首页> 外文期刊>Sao Paulo Medical Journal >Nucleolar Organizer Regions (NORs)
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Nucleolar Organizer Regions (NORs)

机译：核仁组织区（NORs）

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Counts of nucleolar regions (NORs) demonstrated by a silver staining technique in paraffin sections, have been used to distinguish between benign and malignant lesions. AgNORs were studied in 24 biopsies from oral cavity (5 cases of normal oral mucosa, 5 of pseudocarcinomatous hyperplasia and 14 of squamous cell carcinoma, subdivided according to degree of differentiation: 5 grade 1, 5 grade 2 and 4 grade 3) to find whether they were helpful in distinguishing pseudocarcinomatous hyperplasia due to chronic parasitic infections from squamous cell carcinoma. Two methods of counting AgNORs were used: (A) a simpler one which counts nucleolar clusters (AgNU) and satellite AgNORs and the other (B) counting all individual AgNORs, including those within AgNUs. In both methods the lowest mean values were observed for grade 3 carcinoma, while the highest belonged to grade 2 carcinoma. The simpler method (A) was the most useful because AgNU counts showed significant difference when pseudocarcinomatous hyperplasia was compared with grade 1 and 2 carcinomas, which are the most difficult to discriminate from it. However the overlapping of values render the technique of limited use in individual cases.
机译：通过银染技术在石蜡切片中显示的核仁区域（NORs）计数已用于区分良性和恶性病变。对AgNORs进行了24次口腔活检（5例正常口腔粘膜，5例假癌变增生和14例鳞状细胞癌），并根据分化程度进行了细分：5级，5级2级和4级3级。它们有助于区分由于鳞状细胞癌引起的慢性寄生虫感染引起的假癌变增生。使用了两种计算AgNOR的方法：（A）一种更简单的方法，用于对核仁簇（AgNU）和卫星AgNOR进行计数，另一种（B）对所有单个AgNOR（包括AgNU中的单个AgNOR）进行计数。在这两种方法中，均观察到3级癌的最低平均值，而最高值属于2级癌。比较简单的方法（A）是最有用的，因为当将假癌组织增生与最难以区分的1级和2级癌进行比较时，AgNU计数显示出显着差异。但是，值的重叠使得该技术在个别情况下的使用受到限制。

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