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首页> 外文期刊>Sao Paulo Medical Journal >Do Estrogens improve bone mass in osteoporotic women over ten years of menopause
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Do Estrogens improve bone mass in osteoporotic women over ten years of menopause

机译：雌激素在更年期超过十年时能改善骨质疏松妇女的骨量吗

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A retrospective analysis of 24 patients with established osteoporosis and with ten or more years of menopause treated with conjugated estrogen, progesterone and calcium followed for one year has been performed. Treated women received 0.625 mg/day of conjugated estrogen from day 1 to 25, 5 mg/day of medroxiprogesterone from day 13 to 25, of each cycle, plus calcium (500 - 1000 mg/day), during one year (12 cycles). As control group was used 18 age-matched that received only calcium (500 a 1000 mg/day). All patients had at least two dual-photon spine and proximal femur (neck, Ward's triangle and trocanter) densities measurements performed 12 months apart. Estrogen treatment was associated with increased bone mineral density at spine and trocanter. Control group did not present any statistically change after one year in any site studied. We concluded that women with ten or more years of menopause and established osteoporosis treated with replacement hormonal therapy and calcium results in improvement of bone mineral density. These data support that women with ten or more years of menopause respond to estrogen replacement therapy with absolute increments in bone density similar to those seen in younger women, in the early menopause.
机译：回顾性分析了24例已确诊的骨质疏松症患者，并经联合雌激素，孕酮和钙治疗的绝经10年或更长时间，随访了1年。在一年（12个周期）的每个周期中，接受治疗的妇女从第1天到25天每天接受0.625 mg /天的结合雌激素，从第13天到25天每天接受5mg /天的美洛酮酯，再加上钙（500-1000 mg /天）。 。作为对照组，使用了18个年龄相匹配的受试者，仅接受钙（500至1000 mg /天）。所有患者相隔12个月进行至少两次双光子脊柱和股骨近端（颈部，沃德三角形和骨肌）密度测量。雌激素治疗与脊柱和骨的骨矿物质密度增加有关。一年后，对照组在任何研究部位均未出现任何统计学变化。我们得出的结论是，患有更年期十年或更长时间并通过替代激素疗法和钙治疗的骨质疏松症的妇女可改善骨矿物质密度。这些数据表明，绝经十年或更长时间的女性在绝经初期对雌激素替代疗法的反应与对年轻女性的骨密度绝对增加相似。

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