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首页> 外文期刊>Sao Paulo Medical Journal >Metabolic syndrome in patients with prostate cancer
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Metabolic syndrome in patients with prostate cancer

机译：前列腺癌患者的代谢综合征

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CONTEXT AND OBJECTIVE: Prostate cancer (PCa) is the second most common cancer among men in Brazil. Recently, several studies have hypothesized a relationship between PCa and metabolic syndrome (MS). The aim here was to identify an association between MS and PCa. DESIGN AND SETTING: Cross-sectional study, Funda??o de Beneficência Hospital de Cirurgia (FBHC) and Universidade Federal de Sergipe. METHODS: Laboratory and anthropometric parameters were compared between PCa patients (n = 16) and controls (n = 16). RESULTS: The PCa patients showed significantly greater frequency of MS than did the controls (p = 0.034). Serum glucose was higher and high-density lipoprotein-cholesterol was lower than in the controls, although without significant differences. There were significant differences in blood pressure (p = 0.029) and waist-to-hip ratio (p = 0.004). Pearson linear correlation showed a positive association between waist-to-hip ratio and prostate specific antigen (r = 0.584 and p = 0.028). Comparing subgroups with and without MS among the PCa patients, significant differences (p < 0.05) in weight, height, body mass index, hip circumference and lean body mass were observed, thus showing higher central obesity in those with MS. The serum glucose values were also higher in MS patients (p = 0.006), thus demonstrating that insulin resistance has a role in MS physiopathology. CONCLUSIONS: Our study suggests that MS may exert an influence on the development of PCa. However, it would be necessary to expand the investigation field with larger sample sizes and cohorts studied, to test the hypothesis generated in this study.
机译：背景与目的：前列腺癌（PCa）是巴西男性中第二常见的癌症。最近，一些研究假设了PCa与代谢综合征（MS）之间的关系。此处的目的是确定MS与PCa之间的关联。设计与环境：横断面研究，Cirurgia基金会（FBHC）和Sergipe联邦大学。方法：比较了PCa患者（n = 16）和对照组（n = 16）的实验室和人体测量学参数。结果：PCa患者的MS频率明显高于对照组（p = 0.034）。尽管无显着差异，但血清葡萄糖水平较高，高密度脂蛋白胆固醇水平低于对照组。血压（p = 0.029）和腰臀比（p = 0.004）存在显着差异。皮尔逊线性相关性显示腰臀比与前列腺特异抗原之间呈正相关（r = 0.584和p = 0.028）。比较PCa患者中有无MS的亚组，观察到体重，身高，体重指数，臀围和瘦体重的显着差异（p <0.05），因此显示有MS的中枢性肥胖较高。 MS患者的血清葡萄糖值也较高（p = 0.006），这表明胰岛素抵抗在MS生理病理中起作用。结论：我们的研究表明MS可能对PCa的发展有影响。但是，有必要扩大具有更大样本量和研究对象的研究领域，以检验该研究中产生的假设。

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