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首页> 外文期刊>Sao Paulo Medical Journal >Vulvar melanoma: report on eleven cases and review of the literature
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Vulvar melanoma: report on eleven cases and review of the literature

机译：外阴黑色素瘤：11例报道并文献复习

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CONTEXT AND OBJECTIVE: Vulvar melanoma is a rare disease. We describe the experience of a single institution and review the literature. DESIGN AND SETTING: Retrospective study at the Department of Gynecology, Hospital do Cancer A. C. Camargo. METHODS: Eleven patients with vulvar melanoma attended between January 1987 and December 2006 were reviewed regarding clinicopathological characteristics, surgical therapy and follow-up. RESULTS: The initial symptoms were vulvar lesions, pruritus, pain and bleeding. The median age was 64.8 years. The median depth of invasion was 3.08 mm. The staging ranged from IB to IIIC (American Joint Committee on Cancer, 2002). All the patients underwent vulvectomy. Two patients did not undergo primary elective lymphadenectomy. Bilateral inguinal lymphadenectomy was performed on five patients, and one had unilateral inguinal lymphadenectomy. Sentinel lymph node investigation was performed on three patients. Five patients had locoregional recurrence. Prolonged survival was only achieved in the absence of lymph node involvement. The median follow-up was 56 months. The median disease-free survival was 15 months and the median overall survival was 29 months. CONCLUSIONS: The prognosis for patients with vulvar melanoma is generally poor, with a high tendency towards regional and distant recurrence. Depth of invasion and lymph node involvement are the most important prognostic factors. In most cases, resection of the lesion with adequate margins may replace vulvectomy. Elective inguinal femoral lymphadenectomy remains the standard lymph node staging procedure. Sentinel lymph node investigation is feasible and should be performed by a multidisciplinary team with experience of this method.
机译：背景与目的：外阴黑色素瘤是一种罕见的疾病。我们描述了单个机构的经验并回顾了文献。设计与地点：癌症A. C. Camargo医院妇产科的回顾性研究。方法：对1987年1月至2006年12月间就诊的11例外阴黑色素瘤患者的临床病理特征，手术治疗和随访进行了回顾。结果：最初的症状是外阴病变，瘙痒，疼痛和出血。中位年龄是64.8岁。中位浸润深度为3.08mm。分期从IB到IIIC（美国癌症联合委员会，2002年）。所有患者均行外阴切除术。 2例患者未进行原发性选择性淋巴结清扫术。 5例行双侧腹股沟腹股沟淋巴结清扫术，其中1例行单侧腹股沟腹股沟淋巴结清扫术。对三名患者进行了前哨淋巴结检查。五例患者局部复发。仅在没有淋巴结受累的情况下才能达到延长的生存期。中位随访时间为56个月。中位无病生存期为15个月，中位总体生存期为29个月。结论：外阴黑色素瘤患者的预后一般较差，局部和远处复发的趋势较高。浸润深度和淋巴结受累是最重要的预后因素。在大多数情况下，以足够的边缘切除病灶可以代替外阴切除术。选择性腹股沟股骨头淋巴结清扫术仍然是标准的淋巴结分期程序。前哨淋巴结检查是可行的，应由具有此方法经验的多学科团队进行。

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