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首页> 外文期刊>Sao Paulo Medical Journal >xpression of estrogen and progesterone receptor genes in endometrium, myometrium and vagina of postmenopausal women treated with estriol
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xpression of estrogen and progesterone receptor genes in endometrium, myometrium and vagina of postmenopausal women treated with estriol

机译：雌三醇治疗的绝经后妇女子宫内膜，子宫肌层和阴道中雌激素和孕激素受体基因的表达

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CONTEXT AND OBJECTIVE: Estriol is an estrogen with considerably weaker stimulatory effects on endometrial proliferation than estradiol. A study was conducted to determine the level of estrogen receptors (ERs) and progesterone receptors (PRs) in women who received 14-day vaginal estriol therapy, compared with those who did not receive this therapy. ER and PR gene expression was analyzed in the endometrium, myometrium and vagina of postmenopausal women treated with estriol. DESIGN AND SETTING: Analytical cross-sectional study, at the Research Institute of the Polish Mothers' Memorial Hospital, Lodz, Poland. METHODS: Twenty-seven postmenopausal women (57-74 years of age) were included in the study. All of them were waiting for per vaginam hysterectomy or plastic surgery on the vagina and perineum because of uterine prolapse. ER and PR gene expression was determined by means of the technique of reverse transcription polymerase chain reaction (RT-PCR). RESULTS: In the estriol-treated patients, in comparison with the control group, a significant increase in ER gene expression was observed in the endometrium and vagina, while enhanced PR gene expression was found in the endometrium. However, under histological examination of the endometrium, estrogen stimulation of low and medium degree was diagnosed for 21.4% and 14.3% of the estriol-treated women, respectively. CONCLUSION: The results obtained suggest that the women who received 14 days of treatment with vaginal estriol had higher ER and PR mRNA levels. No difference between these groups regarding endometrial proliferation was observed.
机译：背景与目的：雌三醇是一种雌激素，对子宫内膜增殖的刺激作用比雌二醇弱得多。进行了一项研究，以确定接受14天阴道雌三醇治疗的妇女与未接受这种治疗的妇女的雌激素受体（ERs）和孕激素受体（PRs）的水平。在雌三醇治疗的绝经后妇女的子宫内膜，子宫肌层和阴道中分析了ER和PR基因的表达。设计与设置：分析性剖析研究，位于波兰罗兹，波兰母亲纪念医院研究所。方法：27名绝经后妇女（57-74岁）被纳入研究。由于子宫脱垂，他们都在等待每次阴道子宫切除术或对阴道和会阴部进行整形手术。 ER和PR基因表达通过逆转录聚合酶链反应（RT-PCR）技术确定。结果：在接受雌三醇治疗的患者中，与对照组相比，子宫内膜和阴道的ER基因表达显着增加，而子宫内膜的PR基因表达增强。然而，根据子宫内膜的组织学检查，雌三醇治疗妇女的雌激素刺激程度低和中等，分别被诊断为21.4％和14.3％。结论：获得的结果表明接受阴道雌三醇治疗14天的妇女的ER和PR mRNA水平较高。这些组之间在子宫内膜增生方面没有差异。

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