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首页> 外文期刊>Sao Paulo Medical Journal >Bacterial vaginosis in pregnant adolescents: proinflammatory cytokine and bacterial sialidase profile. Cross-sectional study
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Bacterial vaginosis in pregnant adolescents: proinflammatory cytokine and bacterial sialidase profile. Cross-sectional study

机译：怀孕青少年的细菌性阴道病：促炎细胞因子和细菌唾液酸酶谱。横断面研究

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CONTEXT AND OBJECTIVE: Bacterial vaginosis occurs frequently in pregnancy and increases susceptibility to sexually transmitted infections (STI). Considering that adolescents are disproportionally affected by STI, the aim of this study was to evaluate the cervicovaginal levels of interleukin (IL)-1 beta, IL-6, IL-8 and bacterial sialidase in pregnant adolescents with bacterial vaginosis. DESIGN AND SETTING: Cross-sectional study at mother and child referral units in Bel??m, Par??, Brazil. METHODS: Vaginal samples from 168 pregnant adolescents enrolled were tested for trichomoniasis and candidiasis. Their vaginal microbiota was classified according to the Nugent criteria (1991) as normal, intermediate or bacterial vaginosis. Cervical infection due to Chlamydia trachomatis and Neisseria gonorrhoeae was also assessed. Cytokine and sialidase levels were measured, respectively, using enzyme-linked immunosorbent assays and MUAN conversion in cervicovaginal lavages. Forty-eight adolescents (28.6%) were excluded because they tested positive for some of the infections investigated. The remaining 120 adolescents were grouped according to vaginal flora type: normal (n = 68) or bacterial vaginosis (n = 52). Their cytokine and sialidase levels were compared between the groups using the Mann-Whitney test (P < 0.05). RESULTS: The pregnant adolescents with bacterial vaginosis had higher levels of IL-1 beta, IL-6 and IL-8 (P < 0.05). Sialidase was solely detected in 35 adolescents (67.2%) with bacterial vaginosis. CONCLUSIONS: Not only IL-1 beta and sialidase levels, but also IL-6 and IL-8 levels are higher in pregnant adolescents with bacterial vaginosis, thus indicating that this condition elicits a more pronounced inflammatory response in this population, which potentially increases vulnerability to STI acquisition.
机译：背景与目的：细菌性阴道病在孕妇中经常发生，并增加了对性传播感染（STI）的敏感性。考虑到青少年受到性传播感染的影响不成比例，因此本研究的目的是评估患有细菌性阴道病的孕妇青少年的宫颈阴道白细胞介素（IL）-1β，IL-6，IL-8和细菌唾液酸酶水平。设计与地点：在巴西帕尔贝尔市Bel？m的母婴转诊单位进行横断面研究。方法：对来自168名怀孕青少年的阴道样本进行滴虫和念珠菌病检测。根据Nugent标准（1991年）将其阴道微生物群分为正常，中间或细菌性阴道病。还评估了由于沙眼衣原体和淋病奈瑟氏菌引起的宫颈感染。使用酶联免疫吸附测定法和宫颈阴道灌洗液中的MUAN转化分别测量细胞因子和唾液酸酶水平。排除了48名青少年（28.6％），因为他们对所调查的某些感染呈阳性。其余的120名青少年按照阴道菌群类型分组：正常（n = 68）或细菌性阴道病（n = 52）。使用Mann-Whitney检验比较两组之间的细胞因子和唾液酸酶水平（P <0.05）。结果：患有细菌性阴道病的怀孕青少年的IL-1β，IL-6和IL-8水平较高（P <0.05）。仅在细菌性阴道病的35名青少年中检出了唾液酸酶（67.2％）。结论：在细菌性阴道病的孕妇中，不仅IL-1β和唾液酸酶水平升高，而且IL-6和IL-8水平也升高，因此表明该病在该人群中引起了更明显的炎症反应，这可能增加了易感性STI收购。

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