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首页> 外文期刊>Saudi Journal of Gastroenterology >Coexistent ampullary squamous cell carcinoma with adenocarcinoma of the pancreatic duct
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Coexistent ampullary squamous cell carcinoma with adenocarcinoma of the pancreatic duct

机译：并发壶腹鳞状细胞癌和胰管腺癌

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Primary squamous cell carcinoma (SCC) of ampulla has seldom been reported. However, metastatic SCC to ampulla of Vater is well known. We report a case of primary SCC of ampulla of Vater coexistent with well-differentiated adenocarcinoma of the distal pancreatic duct. A 50-year-old female presented with evidence of obstructive jaundice. Endoscopic retrograde cholangio-pancreatography revealed bulging papilla with ulcero-infiltrative growth at the ampulla of Vater. An initial endoscopic biopsy of the ampullary mass showed a well-differentiated SCC. The patient underwent Whipple's operation. Thorough sampling of the dilated portion of the pancreatic duct showed presence of well-differentiated adenocarcinoma of the distal pancreatic duct. Immunohistochemical study with synaptophysin and chromogranin was done with negative result, ruling out neuroendocrine differentiation. Also, a detailed clinical, endoscopic and radiological examination was carried out, that excluded the presence of primary SCC elsewhere.
机译：很少有壶腹原发性鳞状细胞癌（SCC）的报道。然而，转移性SCC至Vater壶腹是众所周知的。我们报告一例原发性SCC的壶腹壶腹与远端胰管高分化腺癌并存。一名50岁女性出现阻塞性黄疸的证据。内镜逆行胰胆管造影显示在Vater壶腹膨出的乳头具有溃疡浸润性生长。最初的内窥镜检查壶腹肿块显示了分化良好的SCC。病人接受了Whipple的手术。胰管扩张部分的彻底取样​​显示，远端胰管存在分化良好的腺癌。用突触素和嗜铬粒蛋白进行的免疫组织化学研究结果为阴性，排除了神经内分泌的分化。此外，还进行了详细的临床，内窥镜检查和放射学检查，排除了其他地方存在原发性SCC的情况。

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