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首页> 外文期刊>Sao Paulo Medical Journal >Leukocyte adhesion deficiency syndrome: report on the first case in Chile and South America
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Leukocyte adhesion deficiency syndrome: report on the first case in Chile and South America

机译：白细胞黏附缺乏综合征：智利和南美地区首例病例报告

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CONTEXT: Adhesion molecule deficiency type 1 is a rare disease that should be suspected in any patient whose umbilical cord presents delay in falling off, and who presents recurrent severe infections. Early diagnostic suspicion and early treatment improve the prognosis. CASE REPORT: The case of a four-month-old boy with recurrent hospitalizations because of severe bronchopneumonia and several episodes of acute otitis media with non-purulent drainage of mucus and positive bacterial cultures is presented. His medical history included neonatal sepsis and delayed umbilical cord detachment. Laboratory studies showed marked leukocytosis with predominance of neutrophils and decreased CD11b and CD18. These were all compatible with a diagnosis of leukocyte adhesion deficiency type I [LAD type 1].
机译：语境：粘附分子缺乏1型是一种罕见的疾病，对于任何脐带延缓脱落，反复发作严重感染的患者，都应怀疑这种疾病。早期诊断怀疑和早期治疗可改善预后。病例报告：病例为一个4个月大的男孩，因严重的支气管肺炎和数次急性中耳炎发作，粘液无脓性引流和阳性细菌培养而反复住院。他的病史包括新生儿败血症和延迟的脐带脱离。实验室研究表明，白细胞增多症以嗜中性粒细胞为主，CD11b和CD18减少。这些都与I型白细胞粘附缺乏症[LAD 1型]的诊断兼容。

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