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首页> 外文期刊>Safety and Health at Work >A Study of Micronucleus Induction with Methyl Formate and 2-Methylbutane in Bone Marrow Cells of Male {ICR} Mice
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A Study of Micronucleus Induction with Methyl Formate and 2-Methylbutane in Bone Marrow Cells of Male {ICR} Mice

机译：甲和2-甲基丁烷在雄性小鼠{{ICR }}小鼠骨髓细胞中诱导微核的研究

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Objectives: We investigated the genotoxicity of two chemicals, methyl formate and 2-methylbutane, using male {ICR} mice bone marrow cells for the screening of micronucleus induction. Although these two chemicals have already been tested numerous times, a micronucleus test has not been conducted and the amounts used have recently been increased. Methods: 7 week male {ICR} mice were tested at dosages of 250, 500, and 1,000 mg/kg for methyl formate and 500, 1,000, and 2,000 mg/kg for 2-methlybutane, respectively. After 24 hours of oral administration with the two chemicals, the mice were sacrificed and their bone marrow cells were prepared for smearing slides. Results: As a result of counting the micronucleated polychromatic erythrocyte (MNPCE) of 2,000 polychromatic erythrocytes (PCE), all treated groups expressed no statistically significant increase of {MNPCE} compared to the negative control group. There were no clinical signs related with the oral exposure of these two chemicals. Conclusion: It was concluded that the two chemicals did not induce micronucleus in the bone marrow cells of {ICR} mice, and there was no direct proportion with dosage. These results indicate that the two chemicals have no mutagenic potential under each study condition.
机译：目的：我们使用雄性 {ICR }小鼠骨髓细胞筛选微核诱导物，研究了甲酸甲酯和2-甲基丁烷这两种化学物质的遗传毒性。尽管已经对这两种化学物质进行了无数次测试，但尚未进行微核测试，并且最近增加了使用量。方法：对7周的雄性{ICR }小鼠的甲酸甲酯剂量分别为250、500和1,000 mg / kg，对2-甲基丁烷的剂量分别为500、1,000和2,000 mg / kg。与两种化学药品一起口服24小时后，处死小鼠，并准备其骨髓细胞用于涂片。结果：作为计数2,000个多色红细胞（PCE）的微核多色红细胞（MNPCE）的结果，与阴性对照组相比，所有治疗组的 {MNPCE }均没有统计学上的显着增加。没有与这两种化学品的口服暴露相关的临床体征。结论：得出结论，这两种化学物质不会在 {ICR }小鼠的骨髓细胞中诱导微核，并且与剂量没有直接的比例。这些结果表明，在每种研究条件下，两种化学物质均无诱变潜力。

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