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首页> 外文期刊>Sao Paulo Medical Journal >Anemia in inflammatory bowel disease: prevalence, differential diagnosis and association with clinical and laboratory variables
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Anemia in inflammatory bowel disease: prevalence, differential diagnosis and association with clinical and laboratory variables

机译：炎症性肠病中的贫血：患病率，鉴别诊断以及与临床和实验室变量的关联

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CONTEXT AND OBJECTIVES:Anemia is the most frequent extraintestinal complication of inflammatory bowel disease. This study aimed to: 1) determine the prevalence of anemia among patients with inflammatory bowel disease; 2) investigate whether routine laboratory markers are useful for diagnosing anemia; and 3) evaluate whether any association exists between anemia and clinical/laboratory variables.DESIGN AND SETTING:Cross-sectional at a federal university.METHODS:44 outpatients with Crohn's disease and 55 with ulcerative colitis were evaluated. Clinical variables (disease activity index, location of disease and pharmacological treatment) and laboratory variables (blood count, iron laboratory, vitamin B12 and folic acid) were investigated.RESULTS:Anemia and/or iron laboratory disorders were present in 75% of the patients with Crohn's disease and in 78.2% with ulcerative colitis. Anemia was observed in 20.5% of the patients with Crohn's disease and in 23.6% with ulcerative colitis. Iron-deficiency anemia was highly prevalent in patients with Crohn's disease (69.6%) and ulcerative colitis (76.7%). Anemia of chronic disease in combination with iron deficiency anemia was present in 3% of the patients with Crohn's disease and in 7% of the patients with ulcerative colitis. There was no association between anemia and disease location. In ulcerative colitis, anemia was associated with the disease activity index.CONCLUSIONS:Most patients present iron laboratory disorders, with or without anemia, mainly due to iron deficiency. The differential diagnosis between the two most prevalent types of anemia was made based on clinical data and routine laboratory tests. In ulcerative colitis, anemia was associated with the disease activity index.
机译：背景与目的：贫血是炎症性肠病最常见的肠外并发症。这项研究旨在：1）确定炎症性肠病患者贫血的患病率; 2）研究常规实验室标记物是否可用于诊断贫血; 3）评估贫血与临床/实验室变量之间是否存在关联。设计与设置：一所联邦大学的横断面。方法：评估44名克罗恩病门诊患者和55名溃疡性结肠炎患者。调查了临床变量（疾病活动指数，疾病的位置和药物治疗）和实验室变量（血液计数，铁实验室，维生素B12和叶酸）。结果：75％的患者存在贫血和/或铁实验室疾病患有克罗恩氏病，溃疡性结肠炎占78.2％。在克罗恩病患者中有20.5％患有溃疡性结肠炎，在溃疡性结肠炎中有23.6％患有贫血。缺铁性贫血在克罗恩病（69.6％）和溃疡性结肠炎（76.7％）患者中非常普遍。患有慢性疾病的贫血与缺铁性贫血相结合的克罗恩病患者占3％，溃疡性结肠炎患者占7％。贫血与疾病位置之间没有关联。在溃疡性结肠炎中，贫血与疾病活动指数有关。结论：大多数患者存在铁实验室疾病，有或没有贫血，主要是由于铁缺乏引起的。根据临床数据和常规实验室检查对两种最常见的贫血类型进行了鉴别诊断。在溃疡性结肠炎中，贫血与疾病活动指数相关。

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