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首页> 外文期刊>Sao Paulo Medical Journal >Metabolic and hematologic changes occurring after rapid intravenous infusion of gammaglobulin in patients with antibody deficiency syndromes
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Metabolic and hematologic changes occurring after rapid intravenous infusion of gammaglobulin in patients with antibody deficiency syndromes

机译：抗体缺乏综合征患者快速静脉滴注丙种球蛋白后发生代谢和血液学变化

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OBJECTIVE: We wished to investigate whether increased IgG infusion rates are associated with metabolic and hematologic changes in pediatric patients with antibody deficiency syndromes. METHODS: We studied 7 patients (2-16 years old) with primary antibody deficiencies who had been on regular IgG replacement treatment, 350-600 mg/kg/dose every 3 weeks with a 3% IVIG preparation, for periods ranging from 6 months to 4 years. Initially, the IgG concentration of IVIG preparations was increased to 6, 9 and 12% in consecutive infusions at a constant IgG infusion rate of 4 mg/kg/min. Subsequently, the infusion rates were increased to 8, 12, and 16 mg/kg/min using the IVIG 12% preparation. RESULTS: Clinically, all patients tolerated increases in IVIG concentrations while the infusion rate was 4 mg/kg/min. However, 3 patients presented side effects when the infusion rate was increased to 8 and 16 mg/kg/min. CONCLUSION: We conclude that metabolic and hematologic sides effects occur with rapid infusion of IVIG even in patients who tolerate the increased infusion rate clinically. The advantages of using high infusion rates have to be re-evaluated.
机译：目的：我们希望调查小儿抗体缺乏综合症患者的IgG输注速率增加是否与代谢和血液学变化有关。方法：我们研究了7例一线抗体缺乏的患者（2-16岁），他们接受常规IgG替代治疗，每3周以3％IVIG制剂治疗350-600 mg / kg /剂量，为期6个月到4年。最初，以4 mg / kg / min的恒定IgG输注速度连续输注时，IVIG制剂的IgG浓度增加至6％，9％和12％。随后，使用IVIG 12％制剂将输注速率提高到8、12和16 mg / kg / min。结果：在临床上，当输注速率为4 mg / kg / min时，所有患者均耐受IVIG浓度的增加。但是，当输注速度增加到8和16 mg / kg / min时，有3例患者出现了副作用。结论：我们得出结论，即使在临床上耐受输注速度增加的患者中，快速输注IVIG也会发生代谢和血液学副作用。使用高输注速率的优势必须重新评估。

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