A liposarcoma is a common soft tissue sarcoma found in adults; however, liposarcomas in the hypopharynx are extremely rare. Here, we report a large liposarcoma originating from the piriform sinus in a female; this is the fifth reported liposarcoma of the hypopharynx in a female, and the first (to our knowledge) liposarcoma in a female that was larger than 20 cm in its largest diameter. The mass was removed using suspension laryngoscopy and diagnosed as a well-differentiated liposarcoma. No recurrence was evident 14 months after surgery.
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