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首页> 外文期刊>Sao Paulo Medical Journal >Post-transplant anemia and associated risk factors: the impact of steroid-free therapy
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Post-transplant anemia and associated risk factors: the impact of steroid-free therapy

机译：移植后贫血及相关危险因素：无类固醇疗法的影响

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CONTEXT AND OBJECTIVE: The prevalence of post-renal transplant anemia (PTA) reported in the literature is variable and several factors contribute towards its pathophysiology. This study aimed to investigate the prevalence of PTA, its associated risk factors and the impact of therapy without steroids. DESIGN AND SETTING: Retrospective cohort study in a renal transplantation unit at a tertiary hospital. METHODS: Anemia was defined as hemoglobin (Hb) 12 g/dl in female adult recipients and 13 g/dl in males. Donor and recipient age and gender, type of donor, creatinine, delayed graft function, acute rejection, use of angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) and therapy without steroids were investigated as risk factors for PTA through multivariate logistical regression analysis. RESULTS: Evaluations were performed on 258 recipients (mean age: 38.8 years; 60.5% males; 35.7% did not receive steroids). Anemia was diagnosed in 38% of the patients (at the sixth month, M6), 28% (M12), 32% (M24) and 45% (at last follow up). Donor age 50 years was associated with greater risks of PTA at M6 (odds ratio (OR) = 4.68) and M24 (OR = 6.57), as well as with therapy without steroids at M6 (OR = 2.96). Delayed graft function was independently associated with PTA at M6 (OR = 3.66) and M12 (OR = 2.85). CONCLUSION: The lowest prevalence of PTA was observed between M9 and M24 after renal transplantation. Delayed graft function, donor age and therapy without steroids were the most important factors associated with PTA.
机译：上下文和目的：文献中报道的肾移植后贫血（PTA）的患病率是可变的，并且有几种因素有助于其病理生理。这项研究旨在调查PTA的患病率，相关的危险因素以及无类固醇疗法的影响。设计与地点：在一家三级医院的肾脏移植单位进行的回顾性队列研究。方法：贫血的定义是成年女性接受者的血红蛋白（Hb）<12 g / dl，男性接受者<13 g / dl。通过多变量研究了供体和受体的年龄和性别，供体类型，肌酐，移植物功能延迟，急性排斥反应，使用血管紧张素转换酶抑制剂（ACEI）或血管紧张素受体阻滞剂（ARB）以及无类固醇的治疗作为PTA的危险因素逻辑回归分析。结果：对258位接受者进行了评估（平均年龄：38.8岁;男性为60.5％;未接受类固醇的为35.7％）。在38％的患者（第六个月为M6），28％（M12），32％（M24）和45％（最后一次随访）中诊断出贫血。供体年龄> 50岁与在M6（优势比（OR）= 4.68）和M24（OR = 6.57）以及在M6时不使用类固醇的疗法（OR = 2.96）的PTA风险更高相关。移植物功能延迟与M6（OR = 3.66）和M12（OR = 2.85）的PTA独立相关。结论：肾移植术后M9和M24之间PTA患病率最低。与PTA相关的最重要因素是移植物功能延迟，捐献者年龄和无类固醇疗法。

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