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首页> 外文期刊>Sao Paulo Medical Journal >Transcranial direct-current stimulation induced in stroke patients with aphasia: a prospective experimental cohort study
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Transcranial direct-current stimulation induced in stroke patients with aphasia: a prospective experimental cohort study

机译：脑卒中失语症患者经颅直流电刺激：一项前瞻性实验研究

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CONTEXT AND OBJECTIVE: Previous animal and human studies have shown that transcranial direct current stimulation can induce significant and lasting neuroplasticity and may improve language recovery in patients with aphasia. The objective of the study was to describe a cohort of patients with aphasia after stroke who were treated with transcranial direct current stimulation. DESIGN AND SETTING: Prospective cohort study developed in a public university hospital. METHODS: Nineteen patients with chronic aphasia received 10 transcranial direct current stimulation sessions lasting 20 minutes each on consecutive days, using a current of 2 mA. The anode was positioned over the supraorbital area and the cathode over the contralateral motor cortex. The following variables were analyzed before and after the 10 neuromodulation sessions: oral language comprehension, copying, dictation, reading, writing, naming and verbal fluency. RESULTS: There were no adverse effects in the study. We found statistically significant differences from before to after stimulation in relation to simple sentence comprehension (P = 0.034), naming (P = 0.041) and verbal fluency for names of animals (P = 0.038). Improved scores for performing these three tasks were seen after stimulation. CONCLUSIONS: We observed that excitability of the primary motor cortex through transcranial direct current stimulation was associated with effects on different aspects of language. This can contribute towards future testing in randomized controlled trials.
机译：语境和目的：先前的动物和人体研究表明，经颅直流电刺激可引起明显且持久的神经可塑性，并可能改善失语症患者的语言恢复能力。该研究的目的是描述经颅直流电刺激治疗的中风后失语症患者的队列。设计与地点：前瞻性队列研究是在一家公立大学医院进行的。方法：19位慢性失语症患者接受连续10天的经颅直流电刺激，每次持续20分钟，使用2 mA电流。阳极位于眶上区域上方，阴极位于对侧运动皮层上方。在10次神经调节会议之前和之后分析了以下变量：口头语言理解，复制，听写，阅读，写作，命名和口语流利度。结果：本研究无不良反应。我们发现，在刺激前后，关于动物名字的简单句子理解（P = 0.034），命名（P = 0.041）和口头流利度（P = 0.038）存在统计学差异。刺激后，可以看到执行这三个任务的分数有所提高。结论：我们观察到经颅直流电刺激对初级运动皮层的兴奋性与对语言各方面的影响有关。这有助于将来在随机对照试验中进行测试。

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