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首页> 外文期刊>Sao Paulo Medical Journal >The relationship of host immune cells, cytokine and nitric oxide production to tumor cells in ovarian carcinoma
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The relationship of host immune cells, cytokine and nitric oxide production to tumor cells in ovarian carcinoma

机译：卵巢癌中宿主免疫细胞，细胞因子和一氧化氮的产生与肿瘤细胞的关系

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AIMS: This brief review focuses on the current understanding of the complex relationship of tumor-associated mononuclear cells (TAMs) with neoplastic cells, summarizing their immunological efficiency, cytokine profile and production of nitric oxide (NO) in the tumor microenvironment, with current insights on how this might affect tumor growth. DATA SOURCE: Data was obtained through Medline from articles indexed during the last 10 years. The main key words used in the research were: cancer, ovarian cancer, cytokine, nitric oxide (NO), mononuclear cell, lymphocyte, macrophage. SELECTION OF STUDIES AND DATA COLLECTION: 30 studies were reviewed, which contained data regarding the production of cytokines and NO by TAMs or malignant cells, and tried to establish a correlation between these mediators and tumor growth, especially in ovarian carcinoma. DATA SUMMARY: TAMs consist mainly of macrophages and T lymphocytes which present lower proliferative indices and cytotoxicity compared to autologous blood monocytes, although they are able to release various cytokines. The profile of cytokine expression could help to explain both the immunological impairment observed in patients with advanced carcinoma diseases and the potential of TAMs to exert antitumor activity, which makes these cells an attractive target for therapeutic intervention. NO is also produced in the tumor microenvironment. Several reports in animals suggest a tumoricidal role for NO, but in human tumors its role has not been well-established and may change during tumor progression.
机译：目的：本文简要综述了肿瘤相关单核细胞（TAM）与肿瘤细胞的复杂关系的当前理解，总结了它们在肿瘤微环境中的免疫学效率，细胞因子谱和一氧化氮（NO）的产生，并具有最新见解。关于这可能如何影响肿瘤生长。数据来源：数据是通过Medline从最近10年被索引的文章中获得的。研究中使用的主要关键词是：癌症，卵巢癌，细胞因子，一氧化氮（NO），单核细胞，淋巴细胞，巨噬细胞。研究的选择和数据收集：回顾了30项研究，其中包含有关TAM或恶性细胞产生细胞因子和NO的数据，并试图建立这些介质与肿瘤生长之间的相关性，特别是在卵巢癌中。数据摘要：TAM主要由巨噬细胞和T淋巴细胞组成，与自体血单核细胞相比，它们具有较低的增殖指数和细胞毒性，尽管它们能够释放多种细胞因子。细胞因子表达谱可以帮助解释在晚期癌症患者中观察到的免疫学损伤，以及TAM发挥抗肿瘤活性的潜力，这使这些细胞成为治疗干预的有吸引力的靶标。在肿瘤微环境中也不会产生NO。动物的一些报道表明，NO具有杀伤作用，但在人类肿瘤中，其作用尚未确定，并且可能在肿瘤进展过程中改变。

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