Thiocyclam does not induce structural chromosome aberrations in human lymphocytes in vitro

Serap Celikler; Kamel Saleh; Mohammed A.A.Sarhan

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Thiocyclam does not induce structural chromosome aberrations in human lymphocytes in vitro

机译：噻菌灵在体外不诱导人淋巴细胞的结构染色体畸变

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Thiocyclam (trade name Evisect) is a broad-spectrum nereistoxin analogue insecticide used widely for agricultural applications. The aim of this investigation was to determine its genotoxic effects in the chromosome aberration (CA) test and determining of mitotic index (MI), using lymphocytes from peripheral blood samples of healthy human donors. A negative and a positive control (MMC) were also included. Chromosomal analyses of the metaphase plates of the samples treated with 14 different concentrations (from 0.1 to 120@mg/ml) of thiocyclam, indicating the lack effect on chromosomes. Thus thiocyclam is not genotoxic but highly toxic on cell proliferation in human lymphocytes.

机译：硫环素（商品名Evisect）是一种广谱的神经营养毒素类似物杀虫剂，广泛用于农业领域。这项研究的目的是使用健康人捐献者外周血中的淋巴细胞，确定其在染色体畸变（CA）测试中的遗传毒性作用并确定有丝分裂指数（MI）。阴性和阳性对照（MMC）也包括在内。用14种不同浓度（0.1至120mg / ml）的硫环素处理的样品的中期板的染色体分析，表明对染色体缺乏影响。因此，噻菌灵对人淋巴细胞的细胞增殖没有遗传毒性，但具有很高的毒性。

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《Saudi Journal of Biological Sciences》 |2010年第3期|共3页
作者
Serap Celikler; Kamel Saleh; Mohammed A.A.Sarhan;
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中图分类生物科学;
关键词
Thiocyclam (Evisect)Chromosomal aberrationsGenotoxicityMitotic indexIn vitro;

机译：硫环素（Evisect）染色体畸变基因毒性有丝分裂指数体外;

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1. Bleomycin-induced genotoxicity in vitro in human peripheral blood lymphocytes evidenced as complex chromosome- and chromatid-type aberrations [J] . Lal Aswathy S., Begum S. Kauser, Bharadwaj Sraddha S., Toxicology in vitro: an international journal published in association with BIBRA . 2019,第期

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2. Radioprotective Effects of Histamine H2 Receptor Antagonists Famotidine and Ranitidine on Gamma-Ray Induced Chromosome Aberration and Micronuclei in vitro in Human Lymphocytes [J] . Narinder Kumar Sharma American Journal of BioScience . 2015,第6期

机译：组胺H2受体拮抗剂法莫替丁和雷尼替丁对人淋巴细胞体外γ射线诱导的染色体畸变和微核的辐射防护作用。
3. Bimolane induces multiple types of chromosomal aberrations in human lymphocytes in vitro. [J] . Roy SK, Eastmond DA Mutation Research: International Journal on Mutagenesis, Chromosome Breakage and Related Subjects . 2011,第2期

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4. Association Study of the Frequencies of Spontaneous and Induced Chromosome Aberrations in Human Lymphocytes [C] . Luybov Salnikova, Anastasia Chumachenko, Alexander V. Rubanovich NATO Advanced Research Workshop on Radiological Issues Pertaining to Environmental Security and Ecoterrorism . 2012

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5. Human immunoglobulin lambda light chain genes and lambda-like genes: Identification and characterization of a new C lambda gene and chromosomal localization and expression of human lambda-like genes in pre-B lymphocytes. [D] . Bauer, Thomas Roy, Jr. 1992

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6. Thiocyclam does not induce structural chromosome aberrations in human lymphocytes in vitro [O] . Serap Celikler, Kamel Saleh, Mohammed A.A. Sarhan 2010

机译：硫环素在体外不诱导人淋巴细胞的结构染色体畸变
7. Thiocyclam does not induce structural chromosome aberrations in human lymphocytes in vitro [O] . Celikler Serap, Saleh Kamel, Sarhan Mohammed A.A. 2010

机译：噻菌灵在体外不诱导人淋巴细胞的结构染色体畸变
8. Radiation-Induced Chromosome Aberrations in Human Lymphocytes. Dose-Response Relationships after Irradiation in Vitro with 200 KV X-Rays and exp 60 Co gamma Rays [R] . Stenstrand, K., Toivonen, H., Rytoemaa, T. 1979

机译：辐射诱导的人淋巴细胞染色体畸变。用200KV X射线和exp 60Coγ射线体外照射后的剂量 - 反应关系

Thiocyclam does not induce structural chromosome aberrations in human lymphocytes in vitro

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